The Effect of Sarcopenia on the Efficacy and Prognosis of HCC Treated With Lenvatinib and Anti-PD-1 Treatment
Trial Snapshot
- Phase
- Not Applicable
- Status
- Enrolling By Invitation
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Short-term results
Study Overview
Brief Summary
Sarcopenia is associated with the prognosis of HCC and cholangiocarcinoma. But there has been rare study focusing on the effect of sarcopenia on the prognosis of HCC treated with lenvatinib and anti-PD1.
Detailed Description
By tracking the short-term and long-term results of HCC patients treated with lenvatinib and anti-PD1,the difference of short-term results between patients with sarcopenia and patients without sarcopenia was analyzed, and the correlation between sarcopenia and short-term and long-term results of patients after systemic treatment was explored, so as to improve people's awareness of sarcopenia and pay attention to its prevention and treatment.All implementation details are based on the newest EWGSOP definition. The investigators consecutively admitted patients the questionnaire and evaluated the assessment of muscle strength (grip strength test and chair stand test), muscle quantity (L3 plane total skeletal muscle area) and physical performance (gait test) following the F-A-C-S approach, to confirm patients with sarcopenia accurately. And by tracking the short-term and long-term outcomes, the differences were analyzed and the relationship between sarcopenia and prognosis of systemic treatment was explored.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with clinical diagnosis of liver cancer
- •No cancer other than liver cancer has been diagnosed
- •Age ≥18 years
Exclusion Criteria
- •Patients who could not complete the standard tests and questionnaires
- •Patients received other therapies
- •Patients who had other causes of muscle weakness (injury, fracture, stroke, etc.)
- •Patients who missing CT data or CT scan did not reach the level of the third lumbar vertebra (L3)
Outcomes
Primary Outcomes
Short-term results
Time Frame: 3 months
Post-treatment complications
Long-term results
Time Frame: 2 years
Overall survival; Progression free survival
Secondary Outcomes
No secondary outcomes reported
Investigators
Gang Chen, MD
Clinical Professor, Principal Investigator
First Affiliated Hospital of Wenzhou Medical University