KCT0001760
Recruiting
未知
Population pharmacokinetic and pharmacodynamic modeling of propofol in underweight patients under general anesthesia
ConditionsNot Applicable
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not Applicable
- Sponsor
- Asan Medical Center
- Enrollment
- 20
- Status
- Recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. 20 yr \< age \<65 yr
- •2\. BMI (body mass index) \< 18\.5 (kg/m2\)
- •3\. Hemoglobin \> 9 g/dl
- •4\. Patients who signed a written informed consent form
Exclusion Criteria
- •1\-1\. Patients with severely impaired respiratory function or respiratory depression status
- •1\-2\. Patients with convulsive disorders, head injury, shock, a reduced level of consciousness of uncertain origin, intracranial lesions or increased intracranial pressure, or in patients with severe hepatic impairment
- •1\-3\. Patients who are concurrently taking other CNS depressants that may cause respiratory depression, hypotension, profound sedation or potentially result in coma
- •1\-4\. Clinically significant impairment of cardiovascular, respiratory and renal function
- •2\. Patients with known hypersensitivity to intervention treatments (propofol) or to any of the excipients
- •3\. Patients who are considered by the investigator to be unsuitable to participate in the study for any other reason not mentioned in the inclusion and exclusion criteria.
Outcomes
Primary Outcomes
Not specified
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