Current Status of Antihypertensive Drug Treatment in Non-cardiac Surgical Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 351
- 试验地点
- 1
- 主要终点
- perioperative blood press(BP)
研究概览
简要总结
A cohort of hypertension patients undergoing elective non-cardiac surgery was constructed to investigate current status of antihypertensive drug treatment in non-cardiac surgical population.
详细描述
Perioperative changes in blood pressure (BP) are associated with perioperative risks. However, there is little information regarding the current status of antihypertensive treatment in non-cardiac surgical population. A cohort of 351 hypertension patients aged between 18 to 85-year old undergoing elective non-cardiac surgery was constructed to investigate the application of antihypertensive drugs, systemic involvement, perioperative hemodynamics and internal environment to grasp the perioperative impact of different antihypertensive drugs, and to further provide a reference for the preoperative antihypertensive strategy of surgery patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing elective non-cardiac surgery with hypertension(i.e., with a systolic blood pressure(SBP) of >=140 mmHg and/or a diastolic blood pressure(DBP) of >=90 mmHg based on the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure) or self-reported use of antihypertensive medication
排除标准
- •Patients under the age of 18 years old
- •Patients more than 85 years old
- •Patients suspected of intracranial hypertension
结局指标
主要结局
perioperative blood press(BP)
时间窗: from the moment on arrival to the operating room until the moment leaving PACU, assessed up to 240 minutes.
baseline BP before the operation, when entering and exiting post-anesthesia care unit(PACU)
次要结局
- pH, base excess, and concentration of HCO3- in blood gases(5 minutes after extubating in PACU)
- the incidence of hypertension in PACU(from the moment on arrival to PACU until 60 minutes after arriving or the moment leaving PACU, whichever came first, assessed up to 240 minutes.)
- the incidence of hypotension in PACU(from the moment on arrival to PACU until 60 minutes after arriving or the moment leaving PACU, whichever came first, assessed up to 240 minutes.)
- hospitalization days(from the date of admission until the date of discharge or date of death from any cause, whichever came first, assessed up to 100 days)