ung Mechanics, Asynchronies, and Flow Limitation in Assisted Invasive Mechanical VENTilatio

Completed

• Conditions: Respiratory failureMechanical ventilation; Respiration, Artificial; Lung Compliance; Airway Resistance; Lung Diseases, Obstructive; Positive-Pressure Respiration, Intrinsic; Respiratory Distress Syndrome, Adult

• Registration Number: TCTR20190318003
• Lead Sponsor: Faculty of Medicine Ramathibodi Hospital Mahidol University, Thailand

Brief Summary

EFL prevalence was 16.5% by PEEP reduction maneuver and associated with higher hospital mortality. We validated an alternative method for EFL detection (the analysis of expiratory resistance or Rex) which showed excellent agreement with PEEP reduction method. Rex analysis can detect 2 subtypes of EFL and we had proposed that they originate from different pathogenesis. These two types of EFL seem to respond differently to the applied PEEP. See the publication for details.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-18
• Study Completion: 2020-10-31
• Results First Posted: 2024-05-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 367

Inclusion Criteria

1. Admitted to the intensive and intermediate critical care wards
2. Receiving invasive mechanical ventilation via a ventilator that is capable of transmitting data through RS-232 port
3. The relatives consent for the patient to participate in the research
4. Permission to do the study is granted from the clinicians in charge
5. Able to initiate the data collection within 48 hours after ventilator use

Exclusion Criteria

1. Severe hypoxemia (SpO2 < 90%) which is uncorrectable
2. Unstable hemodynamics which cannot be corrected (mABP < 60 mmHg, SBP > 180 mmHg, heart rate < 40/min or > 160/min)
3. The patient has already participated in the current study within 48 hours from the previous data collection
4. The patient or the relatives deny to participate in the study
5. Contraindicated to ventilation at ZEEP (ARDS)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The descriptive data regarding lung mechanics, asynchronies and flow limitation 1 hour Data collected via ventilators output port

Secondary Outcome Measures

Name	Time	Method
The predictors of specific lung conditions, asynchronies, or flow limitation 7 days Chart review