TCTR20190318003已完成不适用
ung Mechanics, Asynchronies, and Flow Limitation in Assisted Invasive Mechanical VENTilation (MAFAI VENT project)
Faculty of Medicine Ramathibodi Hospital Mahidol University, Thailand0 个研究点目标入组 367 人开始时间: 2019年3月18日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 367
研究概览
简要总结
EFL prevalence was 16.5% by PEEP reduction maneuver and associated with higher hospital mortality. We validated an alternative method for EFL detection (the analysis of expiratory resistance or Rex) which showed excellent agreement with PEEP reduction method. Rex analysis can detect 2 subtypes of EFL and we had proposed that they originate from different pathogenesis. These two types of EFL seem to respond differently to the applied PEEP. See the publication for details.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 15 Years 至 N/A (No limit)（—）
- 性别
- All
入选标准
- •1. Admitted to the intensive and intermediate critical care wards
- •2. Receiving invasive mechanical ventilation via a ventilator that is capable of transmitting data through RS-232 port
- •3. The relatives consent for the patient to participate in the research
- •4. Permission to do the study is granted from the clinicians in charge
- •5. Able to initiate the data collection within 48 hours after ventilator use
排除标准
- •1. Severe hypoxemia (SpO2 < 90%) which is uncorrectable
- •2. Unstable hemodynamics which cannot be corrected (mABP < 60 mmHg, SBP > 180 mmHg, heart rate < 40/min or > 160/min)
- •3. The patient has already participated in the current study within 48 hours from the previous data collection
- •4. The patient or the relatives deny to participate in the study
- •5. Contraindicated to ventilation at ZEEP (ARDS)
研究者
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