Endothelial Cell Specific Molecule-1 (ESM-1): a Novel Biomarker for ARDS Endothelial Injury

• Conditions: Evaluate the Correlation Between the Level of ESM-1 and the Prognosis of the Patients With ARDS

• Registration Number: NCT03296761
• Lead Sponsor: Jingyuan,Xu

Brief Summary

To observe the changes of plasma ESM-1 levels in patients with ARDS, and to explore its clinical significance.

Detailed Description

70 patients who diagnosed as ARDS were included in this study. Then keep blood samples from these patients in the first day, the third day and the seventh day, detect ESM-1 level in plasma by ELISA. Record Severity of illness and survival status of every patient within 28 days. Objective to evaluate the correlation between the level of ESM-1 in plasma and the prognosis of the patients.

Study Timeline

• Status Verified: 2017-09
• Study First Submitted: 2017-09-25
• Study First Submitted QC: 2017-09-27
• Study First Posted: 2017-09-28
• Last Update Submitted: 2017-10-30
• Study Start: 2017-11-01
• Last Update Posted: 2017-11-01
• Primary Completion: 2017-12-20
• Study Completion: 2018-02-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

1. Patients admitted to ICU diagnosed of ARDS (Berlin definition）in 48h
2. Patients age between 18 years old and 80 years.

Exclusion Criteria：

1. Pregnant women,
2. Patients with malignant tumor,
3. Immunosuppression or immunocompromised patients.

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mortality	28-day

Trial Locations

Locations (1)

Nanjing Zhongda Hospital, School of Medicine, Southeast University; 🇨🇳 Nanjing, Jiangsu, China