Comparative genomics and receptor signaling in MBL and CLL arising in siblings

Recruiting

• Conditions: Monoclonal B-cell lymphocytosis; white blood cells without clinical relevance; 10024324

• Registration Number: NL-OMON41246
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 232

Inclusion Criteria

diagnosis of CLL
or
a sibling with CLL

Exclusion Criteria

n.a.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Definition of genetic differences between MBL en CLL as detected by whole<br /><br>exome sequencing and SNP microarray analysis<br /><br>2) Detection of antigen-independent BCR signaling in MBL en CLL.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>