Evaluation of Vitamin C Administration Effect on Gene Expression of Proinflamatory Cytokines
Phase 2
- Conditions
- nstable condition of bran death patient.liver transplant status
- Registration Number
- IRCT2012061410031N1
- Lead Sponsor
- Vice Chancellor for Research, Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Inclusion criterion: 10-60 y/o confirmed deadbrain case who has the UNOS standard criteria. Exclusion criterion: the deadbrain patient who had a cardiac arrest.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method IL10. Timepoint: Six hours before the operation of deadbrain donor (in intervention group before starting to intervention)- Immediately after laparotomy- Immediately before clamping of Aorta. Method of measurement: Evaluation of Gene Expression pattern of IL10 Cytokine by Real time PCR.;IL1B. Timepoint: Six hours before the operation of deadbrain donor (in intervention group before starting to intervention)- Immediately after laparotomy- Immediately before clamping of Aorta. Method of measurement: Evaluation of Gene Expression pattern of IL1B Cytokine by Real time PCR.
- Secondary Outcome Measures
Name Time Method The serum level of AST. Timepoint: 1, 3 and 10 days after donor transplant. Method of measurement: Measurement of the relevant factor in the blood.;The serum level of Bilirobin -Total. Timepoint: 1, 3 and 10 days after donor transplant. Method of measurement: Measurement of the relevant factor in the blood.;The serum level of ALT. Timepoint: 1, 3 and 10 days after donor transplant. Method of measurement: Measurement of the relevant factor in the blood.