Effect of dexmedetomidine on delirium and postoperative cognitive dysfunction in patients undergoing orthopedic or vascular surgery under regional anesthesia

niversity of Crete0 个研究点目标入组 80 人开始时间: 2020年4月27日最近更新: 2024年7月8日

适应症

试验速览

暂无简介。

•1. Undergoing orthopaedic or vascular surgery under regional anaesthesia
•2. Age >65 years
•3. Medical history and preoperative anaesthetic assessment to allow regional anesthesia to be used
•4. Must know writing and reading
•5. Remain in the hospital for at least four days
•6. Expected postoperative survival is at least one year (on malignant neoplasms) and with a small chance of re-operation within three months

•1. Refuse to receive regional anesthesia or to participate in the study
•2. Central nervous system disease (infectious, metabolic, degenerative, neoplastic, or major psychosis)
•3. Severe vision or hearing impairment
•4. Alcoholics or drug abusers
•5. Severe general condition or in end-stage neoplasm
•6. Contraindications for regional anaesthesia:
•6.1. Coagulation disorders:
•6.1.1. INR> 1.4
•6.1.2. Platelet count <100,000 / µl
•6.1.3. Active/uncontrolled bleeding
•6.1.4. Lack of coagulation factors
•6.1.5. Administration of anticoagulants/antiplatelet drugs in a prophylactic dose for thromboembolic episodes (prior to epidural puncture)
•6.2. Inflammation at the lumbar region
•6.3. Increased intracranial pressure of any cause or CNS tumor
•7. Less than 24 points in the Mini Mental Status Exam during the preoperative assessment

发起方

niversity of Crete