NCT02423304Unknown不适用
A Serological Evaluation of 77A/G and 11A/12A Associated Gene Polymorphisms of MMP-13 in Periodontitis Affected and Healthy Individuals
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre0 个研究点目标入组 100 人开始时间: 2015年5月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 主要终点
- to evaluate the association of 77A/G AND 11A/12A gene polymorphism of mmp-13 in periodontitis effected and healthy individuals
研究概览
简要总结
50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77A/G AND 11A/12A gene polymorphisms of MMP-13
详细描述
- The study will be conducted on 100 individuals
- 50 chronic periodontitis and 50 healthy individuals will be recruited from the Out Patient Department of Periodontics in the study.
- An informed consent will be obtained from patients who wish to participate in the study.
- Patients will be categorized by Periodontal Disease Index (PDI) by P. Ramfjord(1959)
- After clinical examination, blood samples will be collected and assessed for MMP 13 Gene Polymorphisms.
- Subjects will be selected according to the study criteria and divided into two groups (50 each).
- Test group
- Control group
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 30 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Test group
- •Patients with chronic periodontitis classified according to American Academy of Periodontology ( AAP) 1999
- •Subjects aged between 30-55 years
- •Control group Systemically and periodontally healthy individuals of same age group
排除标准
- •Present and past Smokers
- •Presence of any systemic diseases.
- •Oral diseases other than Periodontitis
- •With a previous history of periodontal treatment in the past 6 months and subjects under any medications.
- •Family history of any diagnosed genetic disorders.
结局指标
主要结局
to evaluate the association of 77A/G AND 11A/12A gene polymorphism of mmp-13 in periodontitis effected and healthy individuals
时间窗: 6 months
collect DNA samples from serum and evaluate for gene polymorphism
次要结局
未报告次要终点
研究者
J.surya prasanna
dr.M.Divya Aiswairya
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
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