Serological Evaluation of 77A/G and 11A/12A Gene of MMP-13 in Periodontitis Affected and Healthy Individuals
- Conditions
- Generalized Adult Periodontitis
- Registration Number
- NCT02423304
- Brief Summary
50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77A/G AND 11A/12A gene polymorphisms of MMP-13
- Detailed Description
* The study will be conducted on 100 individuals
* 50 chronic periodontitis and 50 healthy individuals will be recruited from the Out Patient Department of Periodontics in the study.
* An informed consent will be obtained from patients who wish to participate in the study.
* Patients will be categorized by Periodontal Disease Index (PDI) by P. Ramfjord(1959)
* After clinical examination, blood samples will be collected and assessed for MMP 13 Gene Polymorphisms.
* Subjects will be selected according to the study criteria and divided into two groups (50 each).
1. Test group
2. Control group
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
• Test group
-
Patients with chronic periodontitis classified according to American Academy of Periodontology ( AAP) 1999
-
Subjects aged between 30-55 years
- Control group Systemically and periodontally healthy individuals of same age group
- Present and past Smokers
- Presence of any systemic diseases.
- Oral diseases other than Periodontitis
- With a previous history of periodontal treatment in the past 6 months and subjects under any medications.
- Family history of any diagnosed genetic disorders.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method to evaluate the association of 77A/G AND 11A/12A gene polymorphism of mmp-13 in periodontitis effected and healthy individuals 6 months collect DNA samples from serum and evaluate for gene polymorphism
- Secondary Outcome Measures
Name Time Method