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Clinical Trials/NCT01083953
NCT01083953CompletedNot Applicable

Optimal End-Tidal Concentration of Sevoflurane and Desflurane for Removal of Supreme Laryngeal Mask Airway in Anaesthetized Adults

University of Malaya1 site in 1 country54 target enrollmentStarted: November 2009Last updated:
Conditions
Interventions
Drugs

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
54
Locations
1
Primary Endpoint
Optimal end tidal concentration of sevoflurane/ desflurane

Study Overview

Brief Summary

The purpose of this study is to determine the optimal volatile anaesthetic (sevoflurane and desflurane) to remove a Supreme LMA in adults in which there is minimal airway response.

Null hypothesis: there is no significant difference between the optimal end tidal concentration of sevoflurane and desflurane for Supreme LMA removal.

Detailed Description

The manufactures' instructions for removal of the LMA recommend waiting until protective reflexes have returned. However, the appropriate timing for removal remains controversial. A more frequent incidence of airway hyperreactivity and complications has been reported by some studies when the LMA was removed in the awake state versus the anesthetized state. Techniques that reduce the time from LMA removal to the return of protective airway reflexes would minimize the risk of aspiration, contamination, or airway obstruction.

With increasingly common use of Supreme LMA in anaesthetic practice, a safe and suitable depth for removal of the Supreme LMA requires research.

Thus the determination of the optimal end-tidal concentration of commonly used volatile agents ie. Sevoflurane and Desflurane for Supreme LMA removal requires research, both for patient safety and minimising anaesthetic costs in dealing with airway complications.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Supportive Care
Masking
Single (Outcomes Assessor)

Eligibility Criteria

Ages
18 Years to 49 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • ASA 1-2 patients
  • Age 18 - 49 years old
  • Elective surgery of short duration ( < 2 hours ) which require local anaesthetic infiltration

Exclusion Criteria

  • Upper respiratory tract symptoms in the previous 10 days
  • Risk of gastric oesophageal reflux or regurgitation
  • Known or predicted difficult airway
  • Poor dentition with high risk of damage
  • BMI > 30 kg/m2
  • Refusing to participate

Arms & Interventions

Sevoflurane

Experimental

1 arm will receive sevoflurane at varying concentrations at which extubation is attempted according to the Dixon up and down method

Intervention: Sevoflurane (Drug)

Desflurane

Experimental

1 arm will receive desflurane at varying end tidal concentration at which extubation will be attempted according to Dixon up and down method

Intervention: Desflurane (Drug)

Outcomes

Primary Outcomes

Optimal end tidal concentration of sevoflurane/ desflurane

Time Frame: 6 months

Secondary Outcomes

  • presence of airway response(10 mins after surgery)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Cindy Thomas Joseph

doctor

University of Malaya

Study Sites (1)

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