Optimal End-Tidal Concentration of Sevoflurane and Desflurane for Removal of Supreme Laryngeal Mask Airway in Anaesthetized Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Optimal end tidal concentration of sevoflurane/ desflurane
研究概览
简要总结
The purpose of this study is to determine the optimal volatile anaesthetic (sevoflurane and desflurane) to remove a Supreme LMA in adults in which there is minimal airway response.
Null hypothesis: there is no significant difference between the optimal end tidal concentration of sevoflurane and desflurane for Supreme LMA removal.
详细描述
The manufactures' instructions for removal of the LMA recommend waiting until protective reflexes have returned. However, the appropriate timing for removal remains controversial. A more frequent incidence of airway hyperreactivity and complications has been reported by some studies when the LMA was removed in the awake state versus the anesthetized state. Techniques that reduce the time from LMA removal to the return of protective airway reflexes would minimize the risk of aspiration, contamination, or airway obstruction.
With increasingly common use of Supreme LMA in anaesthetic practice, a safe and suitable depth for removal of the Supreme LMA requires research.
Thus the determination of the optimal end-tidal concentration of commonly used volatile agents ie. Sevoflurane and Desflurane for Supreme LMA removal requires research, both for patient safety and minimising anaesthetic costs in dealing with airway complications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ASA 1-2 patients
- •Age 18 - 49 years old
- •Elective surgery of short duration ( < 2 hours ) which require local anaesthetic infiltration
排除标准
- •Upper respiratory tract symptoms in the previous 10 days
- •Risk of gastric oesophageal reflux or regurgitation
- •Known or predicted difficult airway
- •Poor dentition with high risk of damage
- •BMI > 30 kg/m2
- •Refusing to participate
研究组 & 干预措施
Sevoflurane
1 arm will receive sevoflurane at varying concentrations at which extubation is attempted according to the Dixon up and down method
干预措施: Sevoflurane (Drug)
Desflurane
1 arm will receive desflurane at varying end tidal concentration at which extubation will be attempted according to Dixon up and down method
干预措施: Desflurane (Drug)
结局指标
主要结局
Optimal end tidal concentration of sevoflurane/ desflurane
时间窗: 6 months
次要结局
- presence of airway response(10 mins after surgery)
研究者
Cindy Thomas Joseph
doctor
University of Malaya