Optimal End-Tidal Concentration of Sevoflurane and Desflurane for Removal of Supreme Laryngeal Mask Airway in Anaesthetized Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Malaya
- Enrollment
- 54
- Locations
- 1
- Primary Endpoint
- Optimal end tidal concentration of sevoflurane/ desflurane
Study Overview
Brief Summary
The purpose of this study is to determine the optimal volatile anaesthetic (sevoflurane and desflurane) to remove a Supreme LMA in adults in which there is minimal airway response.
Null hypothesis: there is no significant difference between the optimal end tidal concentration of sevoflurane and desflurane for Supreme LMA removal.
Detailed Description
The manufactures' instructions for removal of the LMA recommend waiting until protective reflexes have returned. However, the appropriate timing for removal remains controversial. A more frequent incidence of airway hyperreactivity and complications has been reported by some studies when the LMA was removed in the awake state versus the anesthetized state. Techniques that reduce the time from LMA removal to the return of protective airway reflexes would minimize the risk of aspiration, contamination, or airway obstruction.
With increasingly common use of Supreme LMA in anaesthetic practice, a safe and suitable depth for removal of the Supreme LMA requires research.
Thus the determination of the optimal end-tidal concentration of commonly used volatile agents ie. Sevoflurane and Desflurane for Supreme LMA removal requires research, both for patient safety and minimising anaesthetic costs in dealing with airway complications.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Supportive Care
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 49 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •ASA 1-2 patients
- •Age 18 - 49 years old
- •Elective surgery of short duration ( < 2 hours ) which require local anaesthetic infiltration
Exclusion Criteria
- •Upper respiratory tract symptoms in the previous 10 days
- •Risk of gastric oesophageal reflux or regurgitation
- •Known or predicted difficult airway
- •Poor dentition with high risk of damage
- •BMI > 30 kg/m2
- •Refusing to participate
Arms & Interventions
Sevoflurane
1 arm will receive sevoflurane at varying concentrations at which extubation is attempted according to the Dixon up and down method
Intervention: Sevoflurane (Drug)
Desflurane
1 arm will receive desflurane at varying end tidal concentration at which extubation will be attempted according to Dixon up and down method
Intervention: Desflurane (Drug)
Outcomes
Primary Outcomes
Optimal end tidal concentration of sevoflurane/ desflurane
Time Frame: 6 months
Secondary Outcomes
- presence of airway response(10 mins after surgery)
Investigators
Cindy Thomas Joseph
doctor
University of Malaya