Correlation Between Vitamin D Status and Bone Mineral Density in Patients With Hemophilia

Not Applicable

Completed

• Conditions: Hemophilia A; Hemophilia B; Vitamin D Deficiency

• Registration Number: NCT01090206
• Lead Sponsor: Virginia Commonwealth University

Brief Summary

Study will look at baseline Vitamin D levels, calcium, albumin, liver enzymes, testosterone, osteocalcin, urine N telopeptides, bone mineral density, nutritional assessment and physical activity assessment of boys with hemophilia A or B (ages 2-20 yrs). Patients with low vitamin D levels will receive therapeutic doses of Vitamin D. At end of one year follow up studies will be repeated.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-03
• Study First Submitted: 2010-03-16
• Study First Submitted QC: 2010-03-17
• Study First Posted: 2010-03-19
• Primary Completion: 2013-03
• Study Completion: 2015-03
• Status Verified: 2016-04
• Last Update Submitted: 2016-04-27
• Last Update Posted: 2016-04-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• clinical diagnosis of Hemophilia A or B
• ages 2-21 years

Exclusion Criteria

• therapeutic vitamin D or calcium supplementation within 3 months of study entry

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Correlate between Vitamin D deficiency, low bone mass and lack of weight bearing physical activity	1year

Secondary Outcome Measures

Name	Time	Method
Determine bone mass (density) in hemophilia patients	1 yr
establish dose and duration of treatment with vitamin D	1 yr

Trial Locations

Locations (1)

Virginia Commonwealth University Health System; 🇺🇸 Richmond, Virginia, United States