Vitamin D and Periodontitis
- Conditions
- Alveolar Bone Loss
- Interventions
- Diagnostic Test: fasting venous blood samples
- Registration Number
- NCT03088488
- Lead Sponsor
- T.C. ORDU ÜNİVERSİTESİ
- Brief Summary
Vitamin D has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation. Our aim was to investigate the relation between serum 25-hydroxy vitamin D levels, clinical periodontal parameters and blood serum biomarkers. The subjects were evaluated in 2 groups as chronic periodontitis (n= 30) and periodontally healthy subjects (n= 30). Periodontal parameters and fasting venous blood samples were taken from the subjects to assess each patient's periodontal status and for biochemical analyses (25-hydroxy vitamin D (25-OH vit D), osteoprotegerin (OPG), receptor activator of nuclear kappa B ligand (RANKL), C-telopeptide (CTx), tumor necrosis factor-α (TNF-α)).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- never-smokers
- no history of systemic disease
- no patients had been under periodontal therapy and medicine for at least 6 months before the study
- no pregnancy or lactation
- no alcohol or antioxidant vitamin consumption.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Periodontally healthy subjects fasting venous blood samples - Chronic periodontitis patients fasting venous blood samples -
- Primary Outcome Measures
Name Time Method Biochemical parameters Baseline serum 25-OH vitamin D
- Secondary Outcome Measures
Name Time Method Periodontal parameters Baseline clinical attachment level (CAL)