Gandhaga Mezhugu for treating Urinaray infection

Phase 2

Not yet recruiting

Conditions: Urinary tract infection, site notspecified,

Registration Number: CTRI/2023/09/057245

Lead Sponsor: National Institute of Siddha

Brief Summary: This is an Open labelled, Non randomized, Singlecentric clinical trial to evaluate the effectiveness of *GandhagaMezhugu* in the management of *Neerkiricharam* (UrinaryTract infections). Urinary tract infections (UTIs) are common infections thataffects any part of the urinary system, which includes the kidneys, bladder,ureters, and urethra. UTIs are typically caused by bacteria, with Escherichiacoli (E. coli) being the most common culprit . Every year, around 150 millionUTIs occur worldwide, leading to about $6 billion in healthcare spending. Theusual treatment includes using antibiotics carefully.

However, the growing issue of becomingresistant to antibiotics is causing concern. This resistance can result inlonger and more severe infections, increased healthcare costs, and a greaterrisk of complications. As antibiotic resistance continues to grow, researchersare exploring alternative treatment options to address UTIs effectively.Traditional herbal and mineral-based medicines have gained attention aspotential alternatives to antibiotics. These traditional remedies, derived fromplants, minerals, or other natural sources, have been used in various culturesfor centuries to treat infections and promote overall health.

*Gandhaga Mezhugu*,a herbo-mineral composite, has exhibited antibacterial properties againstprevalent pathogens responsible for urinary tract infections in preclinicalevaluations. This clinical investigation endeavors to systematically ascertainthe efficacy of *Gandhaga Mezhugu*, an established therapeuticapproach for multiple infection conditions. The study will be conducted in OPNo. 11/12, Department of*Gunapadam*, Ayothidoss Pandithar Hospital,National Institute of Siddha, Chenna. Patients will be screened and recruitedto the study based on the inclusion criteria. The sample size is 10 patientsand the study period is 6 months. The outcome is assessed based on the urineculture and decrease/absence of the clinical signs and symptoms.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 10

Inclusion Criteria

1.Presenting with the clinical signs and symptoms of Uncomplicated Urinary Tract infection 2.Patients with positive urine culture for bacterial growth 3.Patients willing to take urine routine, urine culture and radiological investigation.

Exclusion Criteria

1.Patients presenting with signs and symptoms of complicated UTI (those arising in a setting of catheterization, instrumentation, urologic anatomic or functional abnormalities, stones, obstruction, immunosuppression, cancer, renal or hepatic disease) 2.Pregnant and lactating women 3.Known cases of Genitourinary tuberculosis,Diabetes Mellitus, Sexually transmitted diseases like HIV & Syphilis 4.Patient not willing to undergo urine routine and urine culture.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Urine culture test negative for bacterial growth.	14days

Secondary Outcome Measures

Name	Time	Method
Assessment of absence or decreased severity of	clinical signs-symptoms after completion of the

Trial Locations

Locations (1): National Institute of Siddha
🇮🇳
Chennai, TAMIL NADU, India
National Institute of Siddha
🇮🇳Chennai, TAMIL NADU, India
DrDKayalvizhi
Principal investigator
9952993996
drdkayalvizhisiddha@gmail.com