Relationship between coronary artery plaque burden and High Mobility Group Box 1 (HMGB1): prospective cohort study
Not Applicable
- Conditions
- Coronary artery disease
- Registration Number
- JPRN-UMIN000033308
- Lead Sponsor
- Kansai Medical University Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
Not provided
Exclusion Criteria
patients with fever-up, acute and chronic infection, thyroid abnormality, collagen disease, using oral steroid therapy or using inhaled corticosteroid. a patient judged inappropriate by doctor
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of HMGB1 and lipid plaque burden detected by integrated backscatter intravascular ultrasound (IB-IVUS)
- Secondary Outcome Measures
Name Time Method i) Comparison of HMGB1 and instantaneous wave free ratio (iFR) or fractional flow reserve (FFR) in coronary angiography ii) Comparison of HMGB1 and % coronary stenosis calculated by quantitative coronary angiography (QCA) iii) Comparison of HMGB1 and slow flow phenomenon during coronary intervention iv) Comparison of HMGB1 and the grade of coronary collateral vessel v) Comparison of HMGB1 and the incidence of restenosis after coronary intervention vi) Comparison of HMGB1 and the incidence of composite endpoint of cardiac death, myocardial infarction, revascularization and stent thrombosis vii) Comparison of HMGB1 and inflammatory biomarkers of histone H3, syndical-1, lipoprotein(a) and oxidized lipoprotein(a), in addition relationship between these biomarkers and iFR, IB-IVUS and cardiovascular events viii) Comparison of HMGB1 and ankle brachial index (ABI)