Atherosclerotic Carotid Plaque components correlated with Cerebral Damage at 7T

Completed

• Conditions: atherosclerosis; narrowing of the artery; 10003184; 10003216

• Registration Number: NL-OMON34389
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

• Selected for CEA based on (symptomatic or asymptomatic) carotid stenosis (>70%)
• Participation in Athero-Express study
• Adults and of sound mind

Exclusion Criteria

• Patients with a physical handicap (immobility)
• Patients without informed consent
• Allergic reaction to gadolinium in the past
• Impaired renal function (severe renal insufficiency, GFR < 30ml/min/1,73m2; or nephrogenic systemic fibrosis/nephrogenic fibrosing nephropathy (NSF/NFD))
• Impossibility to undergo 7T MRI (claustrophobia, non-removable metal objects in the body)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Specific plaque components (e.g. intra-plaque hemorrhage, neovasculature)<br /><br>correlated with cerebral damage (micro-infarcts, micro bleeds) as seen on the 7<br /><br>Tesla MRI images.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>