In vivo human carotid artery atherosclerotic plaque characterization with high-resolution MRI at 3 and 7T
Withdrawn
- Conditions
- atherosclerosisnarrowing of the artery1000318410003216
- Registration Number
- NL-OMON33964
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 84
Inclusion Criteria
* Selected for CEA based on (symptomatic or asymptomatic) carotid stenosis (>70%)
* Participation in Athero-Express study
* 18 years or older and of sound mind
* Male or female
Exclusion Criteria
* Patients with a physical handicap (immobility)
* Patients with no informed consent
* Allergic reaction to gadolinium in the past
* Impaired renal function (severe renal insufficiency, GFR < 30ml/min/1,73m2; or nephrogenic systemic fibrosis /nephrogenic fibrosing nephropathy (NSF/NFD))
* Impossibility to undergo MRI (claustrophobia, non-removable metal objects in the body)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Number of micro vascular micro infarcts in the perfusion area of the carotid<br /><br>artery associated with specific plaque characteristics.<br /><br><br /><br>To visualize plaque characteristics that have been associated with<br /><br>micro-embolisms and post-operative stroke with<br /><br>high-resolution MRI (3 Tesla and 7 Tesla).<br /><br>Therefore we will mainly look at microvessels (neovasculature) and lipid rich<br /><br>plaques</p><br>
- Secondary Outcome Measures
Name Time Method <p>To visualize all plaque characteristics identified on histology and compare<br /><br>them with the high-resolution MR images (3 Tesla and 7 Tesla).<br /><br><br /><br>golden standard will be the histology<br /><br><br /><br>Comparison of pre- and post operative MR scan aimed at the perfusionstate of<br /><br>the brain. (Evaluate whether the operation<br /><br>improved perfusion in the brain) and whether specitic components are related to<br /><br>the perfusion state/recovery of perfusion state.</p><br>