Study To Investigate Carotid atherosclerosis in carriers of LCAT gene mutations and unaffected family controls: A 3.0 Tesla Magnetic Resonance Imaging study

• Conditions: atherosclerosis; cardiovascular disease; 10027424; 10003216

• Registration Number: NL-OMON32476
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Subjects who are carriers of LCAT gene mutations, aged between 18 and 75 years of age, and healthy unaffected family controls, aged between 18 and 75 years, matched for age, gender, body mass index (BMI, in kg/m2) and smoking.

Exclusion Criteria

Metal in the body, as a result of e.g. osteosynthetic material, pacemaker or artificial cardiac valves; claustrophobia; surgery performed in the area of measurement (Carotid artery region); cardiac arrhythmias.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>mean wall area of carotid arteries as assessed by MRI</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>