Optimizing diagnosis of splanchnic vein thrombosis with MR Direct Thrombus Imaging.

Recruiting

Conditions: abdominal vein thrombosis
Splanchnic vein thrombosis
10014523

Registration Number: NL-OMON52628

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

- Patients with confirmed acute SVT; definitions provided in paragraph 4.2 in
the Rhea study protocol (Cases, group 1)
- Patients with confirmed non-symptomatic chronic SVT, defined by incident SVT
with chronic thrombi on 2 serial imaging tests with at least 3 months interval
(controls, group 2)
- Aged 18 years and older
- Willing and able to give informed consent

Exclusion Criteria

- MRI contra-indication (including but not limited to a cardiac pacemaker or
subcutaneous defibrillator; vascular clips in the cerebral vessels; metal
splinter in the eye, a hearing aid that cannot be removed; a neurostimulator
that cannot be removed; a hydrocephalus pump)
- A medical condition, associated illness or co-morbid circumstances that
precludes completion of the study procedures (MRI and 90-day follow-up
assessment), including but not limited to life-expectancy less than 3 months,
inability to lie flat, morbid obesity preventing use of MR and claustrophobia.
- Patients with decompensated liver disease with Child-Pugh class C cirrhosis
(since MRDTI evaluation will be inadequate in these patients)
- Patients with suspected tumour thrombus

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The sensitivity and specificity of MRDTI for the diagnosis of acute and chronic<br /><br>SVT</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary endpoints are<br /><br>1) optimized MRDTI scan sequences for SVT;<br /><br>2) the assessment of interobserver agreement between the reviewers. </p><br>