Does Sedation Depth (as Evaluated by the Bispectral Index) Influence Dynamic Indices of Preload Dependence?
Completed
- Conditions
- Thoracic Surgery
- Registration Number
- NCT02812758
- Lead Sponsor
- Centre Hospitalier Universitaire, Amiens
- Brief Summary
Dynamic indices of preload dependence (such as stroke volume variability -SVV , pulse pressure variability - PPV and plethysmograph variability index - PVI ) are reportedly predictive of the response to vascular filling in sedated, mechanically ventilated patients. However, the influence of the sedation depth on these dynamic indices has never been evaluated.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
- All sedated, intubated, mechanically ventilated adult (over-18) patients admitted for elective cardiac surgery, monitored for sedation depth (with the BIS) and for preload dependence indices (SVV, PPV and PVI)
- Good echogenicity
- Social security coverage
Exclusion Criteria
- Pregnancy, legal guardianship
- Subjects with black skin (a known technical limitation of plethysmography)
- Cardiac arrhythmia
- Sepsis
- Poor echogenicity
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Values of the dynamic indices (SVV, PPV and PVI) at different sedation levels (as evaluated by the BIS) Day 0
- Secondary Outcome Measures
Name Time Method The proportion of patients that change their preload dependence status during a change in sedation depth (as evaluated by the BIS). Day 0
Trial Locations
- Locations (1)
CHU Amiens
🇫🇷Amiens, France
CHU Amiens🇫🇷Amiens, France