Evaluating the Use of VExUS along with Standard Care for Guiding fluid removal therapy in Children Aged 5-18 with Acute Kidney Injury: A Pilot Study

Phase 3

Not yet recruiting

• Conditions: Acute kidney failure,

• Registration Number: CTRI/2025/04/084654
• Lead Sponsor: AIIMS BHOPAL

Brief Summary

Assessment of volume status is critical in all children with Acute kidney injury (AKI). Peripheral signs of fluid overload did not correlate with AKI, which reemphasizes the fact that they might not truly reflect  the intravascular volume status. Central venous pressure  determination is an invasive procedure and it’s values  can be influenced by  various factors. Over  the past years point of care ultra sound (POCUS) is identified  as a non invasive bedside  monitor for evaluating venous congestion and this  helps to monitor  the response  to decongestive therapy .Venous excess ultrasound (VExUS)  is emerging as a valuable bed side tool to gain real time hemodynamic insights. The present  study  aimed to establish the usefulness of the VExUS  score in children with AKI for detecting systemic venous congestion and directing the decongestive therapy in comparison with current standard of care for AKI in children .To date there is paucity of literature on applicability and usefullnes of VExUS score a an estimator of the degree of venous congestion in pediatric patients. This study will be one of  the first in evaluation of performance and utility of VExUS in children.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-02-04
• Study Start: 2025-04-14

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Children aged 5 to 18 years with acute kidney injury (AKI) admitted in Pediatric department of AIIMS Bhopal.

Exclusion Criteria

• i.All children with who are eligible, whose parents refuse to give written informed consent.
• ii.Children diagnosed with CKD stage 3 or above.
• iii.All children who are already diagnosed with chronic liver disease, Budd Chiari syndrome, moderate to severe tricuspid regurgitation, chronic pulmonary hypertension.
• iv.All children who anatomical abnormality of liver v.All children with renal vascular abnormality, gross hydronephrosis and cystic kidney disease vi.All children who had received RRT prior to hospital admission.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Renal replacement therapy free days during the initial 28 days in children with Acute Kidney Injury	28 days after diagnosis of AKI in child
Mortality in children with Acute Kidney injury in both groups	28 days after diagnosis of AKI in child

Secondary Outcome Measures

Name	Time	Method
To evaluate the occurrence Intradialytic hypotension in children with AKI receiving RRT in both group	Initial 7 days after diagnosing Acute kidney injury in child
Cumulative fluid overload in both the group at the end day 7 of enrolment	Initial 7 days after diagnosing Acute kidney injury in child
To evaluate the requirement of total diuretic dose in both groups	Initial 7 days after diagnosing Acute kidney injury in child
To evaluate the correlation of VExUS score with need of RRT
To evaluate the proportion of children with AKI developing dyselectrolytemia (in terms of sodium, potassium and calcium disturbances) in both groups.	Initial 7 days after diagnosing Acute kidney injury in child

Trial Locations

Locations (1)

AIIMS BHOPAL; 🇮🇳 Bhopal, MADHYA PRADESH, India

AIIMS BHOPAL

🇮🇳Bhopal, MADHYA PRADESH, India

ATHIRA P

Principal investigator

9746793207

athirapgmc@gmail.com