Effect of Topiramate in treatment of chronic schizophrenia
- Conditions
- Schizophrenia.Schizophrenia
- Registration Number
- IRCT138904014236N1
- Lead Sponsor
- Mashad university of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Inclusion criteria
1. All the patients who meet the full criteria of chronic and treatment resistant schizophrenia disorder, based on DSMIV-TR
2. Ages of subjects were between 25 to 65 years
3. All patients were hospitalized for at least 6 month before the study
4. All patients were being treated with Clozapin
Exclusion criteria
1. Chronic diseases including diabetes, hypertension, history of kidney stone, epilepsy and substance abuse
2. An ongoing medical treatment
3. Elevated PANSS score up to 30%
4. Adverse effects associated with therapy including dizziness, agitation, hypertension, allergy to medications
5. Medical problems need to be treated such as diarrhea, urinary infection, cardiovascular disease, and trauma.
6. Temporary or permanent discharge from hospital while in study
7. Developing new psychiatric symptoms such as manic or hypomanic episode, panic attack
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method