Study of C-reactive protein in acute febrile illness in children aged 1 to 36 months

This prospective observational study aims to evaluate the role of C-reactive protein (CRP) as a diagnostic marker for identifying serious bacterial infection (SBI) in children aged 1–36 months presenting with acute febrile illness. Young children with fever often present without clear localizing signs, making early differentiation between bacterial and viral infections challenging. Early and accurate identification of SBI is crucial to prevent complications and reduce unnecessary antibiotic use.

In this study, CRP levels will be measured at presentation and correlated with definitive clinical and laboratory diagnoses of serious bacterial infection. The diagnostic performance of CRP—including its sensitivity, specificity, and predictive value—will be analyzed to determine its usefulness as an early screening tool in this age group.

The findings may help guide clinical decision-making and improve management strategies for febrile young children.