High Flow Nasal Cannula to Prevent Deoxygenation During Induction of General Anesthesia in Cesarean Section

Not Applicable

• Conditions: Hypoxic Brain Injury; Maternal Death
• Interventions: Other: H Group; Other: F Group

• Registration Number: NCT04438798
• Lead Sponsor: Alexandria University

Brief Summary

Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) using high flow oxygen therapy for preoxygenation and oxygen supplementation during apnoea has shown promising results

Detailed Description

Eeffective preoxygenation followed by apnoeic oxygenation enables anaesthesiologists to safely prolong the apnoea time which is the time (seconds) of apnea following preoxygenation and muscle relaxation before to peripheral oxygen saturations (SpO2) decreases by 2%.

Study Timeline

• Study First Submitted: 2020-06-17
• Study First Submitted QC: 2020-06-17
• Study First Posted: 2020-06-19
• Study Start: 2020-07-01
• Status Verified: 2020-08
• Last Update Submitted: 2020-08-16
• Last Update Posted: 2020-08-18
• Primary Completion: 2020-10-01
• Study Completion: 2020-11-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• pregnant females
• Of American Society of Anesthesiologists (ASA) physical Status I and II
• For elective cesarean section under general anesthesia

Exclusion Criteria

• with room air saturation of <98%
• anticipated difficult airway
• anticipated obstetric risk factor or precious baby
• chronic obstructive pulmonary disease
• thyrotoxicosis
• pheochromocytoma
• hyperkalaemia
• significant cardiac illness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
THRIVE group	H Group	High-flow humidified oxygen warmed to 37°C will be delivered through nasal cannula at the rate of 30 L/ min for 30 seconds then 50 liters per minute for a further 150 seconds.
face mask group	F Group	Pregnant females will be preoxygenated with 100% oxygen using a tight-fitting face mask at a rate of 6 L/min for 3 min with end-tidal gas monitoring.

Primary Outcome Measures

Name	Time	Method
measure the time of safe apnea	10 minutes after induction	The apnea time will start from the onset of cessation of breathing as evidenced by a flat line in the capnogram with the absence of chest movements

Trial Locations

Locations (1)

Rehab Abd Elraof Abd Elaziz; 🇪🇬 Alexandria, Egypt