COMPARATIVE STUDY OF SEVOFLURANE AND ISOFLURANE ON HEMODYNAMIC STABILITY ON PATIENTS UNDERGOING LAPAROSCOPIC SURGERY: A RANDOMIZED CLINICAL TRIAL

Laparoscopic surgeries have gained widespread acceptance across various surgical specialties due to their minimally invasive nature, reduced post operative pain, quicker recovery, and shorter hospital stays. Despite these advantages, laparoscopic procedures are associated with physiological alterations, including increased intraabdominal pressure and Carbon dioxide insufflation, which can pose significant challenges to maintaining hemodynamic stability during anesthesia. This becomes particularly important in patients safety and operative outcomes.

The present study is a prospective, randomized, and comparative clinical trial aimed at evaluating and comparing the effects of sevoflurane and isoflurane on intraoperative hemodynamic stability and post anesthesia recovery in patients undergoing various elective laparoscopic surgeries under general anesthesia.

A total of 84 patients, aged from 18 to 60 years and classified as ASA Grade I or II, scheduled for elective laparoscopic procedures, were enrolled in the study and randomly assigned into two equal groups

Group A    42 patients to receive sevoflurane for maintenance of anesthesia

Group B    42 patients to receive isoflurane for maintenance of anesthesia

All patients received standardized premedication and were induced with intravenous agents. Anesthesia was maintained with a mixture of oxygen and nitrous oxide , supplemented with either isoflurane or sevoflurane, titrated to maintain adequate depth of anesthesia by using MAC value and stable hemodynamic parameters.

Throughout the perioperative period, heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure were closely monitored. Postoperative recovery characteristics were also assessed, including

Time to eye opening

Response to verbal commands

Time to extubation

Modified aldrete score