Surgical Stress After Laparoscopic Compared to Open Liver Resection

Not Applicable

Completed

• Conditions: Insulin Resistance

• Registration Number: NCT01819688
• Lead Sponsor: Sir Run Run Shaw Hospital

Brief Summary

The purpose of this study is to determine whether the postoperative insulin resistance and cytokine release would be attenuated in laparoscopic compared with open liver resection.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-08
• Primary Completion: 2008-11
• Study Completion: 2008-11
• Status Verified: 2013-03
• Study First Submitted: 2013-03-20
• Study First Submitted QC: 2013-03-22
• Last Update Submitted: 2013-03-22
• Study First Posted: 2013-03-27
• Last Update Posted: 2013-03-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

• ASA 1-2
• left hemihepatectomy(liver resection)
• left lateral sectionectomy(liver resection)

Exclusion Criteria

• Patients with diabetes mellitus
• drug abuse
• BMI >24 or <18

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
postoperative insulin resistance calculated by serum insulin and blood glucose	within the first 72hrs after operation	At baseline prior to surgery, and 3hr, 12hr, 24hr, 72hrs after operation, blood glucose and insulin was measured.; Insulin resistance is assessed by the HOMAIR(homeostatic model assessment of insulin resistance) score which is calculated through the mathematic formula: HOMAIR= FI ×FG/22.5, where FI= fasting serum insulin(μU/mL), FG= fasting plasma glucose (mmol/L), and 22.5 is a constant.

Secondary Outcome Measures

Name	Time	Method
cytokine changement including IL-1β, IFN-γ, IL-4 and IL-10 before and after operation	within 5 days after operation	At baseline before operation and 0, 3hr, 12hr, 24hr, D3, D5 after operation, duplicated samples were drawn to analyze serum IL-1β, IFN-γ, IL-4 and IL-10.

Trial Locations

Locations (1)

Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University; 🇨🇳 Hangzhou, Zhejiang, China