Cerebral Hemodynamics in Sleep Disorders
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- phase difference(PD) in degree
研究概览
简要总结
The purpose of this study is to determine the relationship between sleep disorders and cerebral hemodynamics.
详细描述
Sleep disorders continue to be the most unrecognized modifiable risk factor for stroke. The relationship between sleep disorders and vascular risk factors and stroke has been well-documented but not fully understood. The investigators hypothesize hemodynamics impairment to be its potential mechanism. It has been reported that sleep-related breathing disorder, a type of sleep disorders, contributed as a risk factor for stroke through hemodynamic and hematologic changes. The purpose of this study is to determine the relationship between different kind of sleep disorders and cerebral hemodynamics, including OSHAS, RLS, RBD, narcolepsy, etc. The dynamic cerebral auto-regulation (dCA) and Transcranial Doppler (TCD) will be used to evaluate cerebral hemodynamics.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with sleep disorders
- •meet the Diagnostic Criteria for Sleep Dyssomnias
- •sufficient bilateral temporal bone windows for insonation of the MCA
排除标准
- •middle cerebral artery (MCA) and/or other intracranial and/or extracranial major vascular 4 stenosis/occlusion, as diagnosed by a transcranial Doppler
- •having a prior symptomatic cerebral vascular disease
- •current arrhythmia, hyperthyroidism, anemia and unstable blood pressure, which may undermine hemodynamic stability
- •inability to cooperate sufficiently to complete the dCA examination
结局指标
主要结局
phase difference(PD) in degree
时间窗: 6 months
A dynamic cerebral auto-regulation parameter derived from transfer function analysis.Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the autoregulatory parameters.
the rate of recovery of cerebral blood flow velocity
时间窗: 6 months
A dynamic cerebral auto-regulation parameter derived from transfer function analysis.The details are same as outcome 1
gain in cm/s/mmHg
时间窗: 6 months
A dynamic cerebral auto-regulation parameter derived from transfer function analysis.The details are same as outcome 1
次要结局
- mean MCA blood flow velocity (mCBFV) changes from supine to upright position(6 months)
- resistance index (RI) changes from supine to upright position(6 months)
- pulsatility index (PI) changes from supine to upright position(6 months)
研究者
Yi Yang
Associated Dean of First Hospital of Jilin University
The First Hospital of Jilin University