Sleep Disordered Breathing and Alzheimer's Disease Biomarkers in Normal Aging and Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Decreased cerebral blood flow (CBF)
研究概览
简要总结
The purpose of this study is to determine the sleep patterns of subjects with or without sleep disturbances (insomnia, sleep apnea) and compare these findings with their previous FDG/PIB PET, structural MRI and brain blood flow scams performed during their participation in the Following studies 'Alzheimer's Disease Core Center (ADCC) Clinical Evaluation' (IRB: 2942), MRI Progression Markers of Cognitive Decline in the Elderly' (IRB:09-0586), or 'Imaging Neuro inflammation in Alzheimer's Disease with [11C] Arachidonic Acid (AA) and PET'(IRB: 10-00442).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 55 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All subjects will have participated in prior CBH studies and have agreed to an FDG, PIB and MRI scans.
排除标准
- •Diagnosis of sleep apnea and under treatment with a continuous positive airway pressure (CPAP) machine.
- •Active depressive episode during the evaluation with a Geriatric Depression Scale score >7 and/or a Clinical Global Impression scale for depression score >
- •Moderate Cognitive decline (GDS >3).
- •Severe primary or secondary insomnia except insomnia due to SDB.
结局指标
主要结局
Decreased cerebral blood flow (CBF)
时间窗: 1 Week
Measured by perfusion MRI
Measure of vasoreactivity to CO2 (VRCO2)
时间窗: 1 Week
subjects will breath through a respiratory tube and CO2 will be meaured
Increase in cortical AB plaque burden
时间窗: 1 Week
Measured by PIB PET
次要结局
未报告次要终点