Serum and Urine Ghrelin in Adult Epileptic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Urine ghrelin in Adult Epileptic Patients
研究概览
简要总结
Several neuropeptides have concerned with epilepsy pathogenesis, ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drugs (AED) response.
详细描述
Several neuropeptides have concerned with epilepsy pathogenesis, ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drugs (AED) response. Objective: to evaluate ghrelin effect in adult epileptic patients and in response to AED. Methods: This case control study included 40 adult epileptic patients and 40 healthy controls. Participants were subjected to history taking of seizure semiology, full general and neurological examination, electroencephalography and cranial CT or MRI. Fasting serum acylated ghrelin (AG) and unacylated ghrelin (UAG) and urine AG levels were estimated to all participants by enzyme - linked immunosorbent assay (ELIZA).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All participants were included if their age more than or equal to 18 years. Body mass index < 30 kg/m2, total cholesterol < 200mg/dl, serum triglycerides < 200 mg/dl and random blood glucose level < 126 mg/dl.
排除标准
- •Participants had acute or chronic metabolic disorders (liver, kidney, thyroid, endocrine or gastrointestinal disorders).
- •Females with irregular menstrual cycle or on estrogen therapy (7).
- •Participants with organic cerebral lesion that was detected on cranial computed tomography (CT) or cranial magnetic resonance imaging (MRI).
结局指标
主要结局
Urine ghrelin in Adult Epileptic Patients
时间窗: 6 months
evaluation of the effect of Urine ghrelin in adult epileptic patients and in their response to anti- epileptic drugs
Serum ghrelin in Adult Epileptic Patients
时间窗: 6 months
evaluation of the effect of Serum ghrelin in adult epileptic patients and in their response to anti- epileptic drugs
次要结局
未报告次要终点
研究者
rania sanad
Principal Investigator
Zagazig University