Cortical Correlations Between Fine Manual Motor Skills and Speech Articulation : Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Recording of brain activity during manual motor skills and speech articulation
研究概览
简要总结
The aim of this study is to examine the relationship between cerebral motor control during a manual task and during an articulary task, using functional MRI in a cohort or young adults aged between 18 and 35.
The literature reveals a well-established relationship between manual motor skills and speech from an anatomical and functional point of view. Some studies indicate a proximity between the motor cortical regions corresponding to the hand and the mouth, with a mutual interaction of the two functions from the earliest stages of life (for example, the Babkin reflex). Experimental data shows that hand movements can be influenced by mouth movements. Neurophysiological studies have demonstrated the existence of a link between these two systems in humans and monkeys.
To date, no study has identified the common cortical networks that are active during these two limb movements in a given sample of subjects. The aim of this study is to determine whether such networks exist. The results could be therapeutically relevant, particularly for stroke patients, by enabling more effective restoration of articulatory abilities through complementary limb movements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female between the ages of 18 and 35
- •Right-handed
- •Member of beneficiary of a social security insurance
- •Signature of an informed consent
排除标准
- •Disorders of fine manual motor skills and/or articulatory disorders
- •A neurological history that has affected the subject's cerebral function (stroke, head injury)
- •Contraindication to MRI (presence of ferromagnetic material in the body, claustrophobia)
- •Pregnant women
- •Taking medication that may alter the cerebral haemodynamic signal
研究组 & 干预措施
Motor tasks and oral and facial language
Exercises and MRI
干预措施: Tasks learning and MRI scan (Other)
结局指标
主要结局
Recording of brain activity during manual motor skills and speech articulation
时间窗: 2 weeks after inclusion
Detection and comparison of fMRI image sequences of brain areas based on variations in the difference between oxygenated and deoxygenated hemoglobin during manual motor tasks and silent phoneme articulation
次要结局
未报告次要终点
