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临床试验/NCT06908863
NCT06908863招募中不适用

Cortical Correlations Between Fine Manual Motor Skills and Speech Articulation : Pilot Study

Centre Hospitalier Universitaire de Nice1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2025年10月13日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
20
试验地点
1
主要终点
Recording of brain activity during manual motor skills and speech articulation

研究概览

简要总结

The aim of this study is to examine the relationship between cerebral motor control during a manual task and during an articulary task, using functional MRI in a cohort or young adults aged between 18 and 35.

The literature reveals a well-established relationship between manual motor skills and speech from an anatomical and functional point of view. Some studies indicate a proximity between the motor cortical regions corresponding to the hand and the mouth, with a mutual interaction of the two functions from the earliest stages of life (for example, the Babkin reflex). Experimental data shows that hand movements can be influenced by mouth movements. Neurophysiological studies have demonstrated the existence of a link between these two systems in humans and monkeys.

To date, no study has identified the common cortical networks that are active during these two limb movements in a given sample of subjects. The aim of this study is to determine whether such networks exist. The results could be therapeutically relevant, particularly for stroke patients, by enabling more effective restoration of articulatory abilities through complementary limb movements.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Male or female between the ages of 18 and 35
  • •Right-handed
  • •Member of beneficiary of a social security insurance
  • •Signature of an informed consent

排除标准

  • •Disorders of fine manual motor skills and/or articulatory disorders
  • •A neurological history that has affected the subject's cerebral function (stroke, head injury)
  • •Contraindication to MRI (presence of ferromagnetic material in the body, claustrophobia)
  • •Pregnant women
  • •Taking medication that may alter the cerebral haemodynamic signal

研究组 & 干预措施

Motor tasks and oral and facial language

Experimental

Exercises and MRI

干预措施: Tasks learning and MRI scan (Other)

结局指标

主要结局

Recording of brain activity during manual motor skills and speech articulation

时间窗: 2 weeks after inclusion

Detection and comparison of fMRI image sequences of brain areas based on variations in the difference between oxygenated and deoxygenated hemoglobin during manual motor tasks and silent phoneme articulation

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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