Comparing the effectiveness of two treatment protocols: dexmedetomidine - propofol and midazolam - fentanyl - propofol in relieving pain in patients undergoing extracorporeal stone crusher

Phase 4

Recruiting

• Conditions: Patients with Calculus of kidney.; Calculus of kidney; N20.0

• Registration Number: IRCT20230701058625N1
• Lead Sponsor: Dezfoul University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 16 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients with kidney stones below 2cm and proximal ureter for ESWL aged 18 to 80 years with American Society of Anesthesiologists (ASA) physical status I, II or III who consent to participate in this study will be eligible for this study.

Exclusion Criteria

Patients who do not agree to participate in this study
Patients with chronic liver failure
Patients who have a history of allergy to this drug or other alpha-adrenergic drugs
Patients with a history of bradycardia and low blood pressure
Patients with coagulation disorders
Patients with a history of allergy to drugs used to treat ESWL
Patients with mental disorders, nervous disorders and skin disorders (inflammation).
Patients with active infection
Patients who are pregnant
Patients who have uremia
Patients with BMI > 25
Patients who have used painkillers 12 hours before visiting
Patients who have pain before visiting

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma level of Substance P in patients. Timepoint: At the beginning of the study and one week after lithotomy of the patients. Method of measurement: Measuring the Plasma level with ELISA.;Pain. Timepoint: At the beginning of the study and one week after lithotomy of the patients. Method of measurement: The person is shown a scale from 0 to 10 and the person gives a score from 0 to 10 on the level of pain felt. (Visual Analogue Scale).

Secondary Outcome Measures

Name	Time	Method
Blood pressure. Timepoint: Two times, before ESWL and one week after ESWL. Method of measurement: Manual sphygmomanometer.;Respiratory rate. Timepoint: Two times, before ESWL and one week after ESWL. Method of measurement: clinical examination.;Nausea and Vomiting. Timepoint: Two times, before ESWL and one week after ESWL. Method of measurement: Event occur.