跳至主要内容
临床试验/NCT06707298
NCT06707298尚未招募不适用

The Role of Multidetector Computed Tomography(MDCT) in Grading of Oesophageal Varices in Cirrhotic Patients in Comparison to Endoscopy

Assiut University0 个研究点目标入组 70 人开始时间: 2024年12月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
70
主要终点
Comparison between CT and endscopy in esophageal varices

研究概览

简要总结

Esophageal varices are one of the major complications of liver cirrhosis.Accurate grading of these varices is essential for effective management . Traditionally, esophagogastroduodenoscopy is the gold standard for diagnosing and grading esophageal varices,Multi detector computed tomography (MDCT) has emerged as a non-invasive alternative for evaluating esophageal varices.it particularly appealing for patients who contraindicated to endoscopy .

详细描述

Esophageal varices are one of the major complications of liver cirrhosis, with an estimated prevalence of approximately 80% with decompensated patients and 50% in compensated cirrhosis, pose a significant risk of life-threatening of bleeding due to portal hypertension. Accurate grading of these varices is essential for effective management . Traditionally, esophagogastroduodenoscopy (EGD) is the gold standard for diagnosing and grading esophageal varices . IT provides direct visualization, allowing for detailed assessment of variceal size and other risk factors for bleeding . However, it is an invasive procedure that requires sedation and carries some risks, such as bleeding or perforation .

Multi detector computed tomography (MDCT) has emerged as a non-invasive alternative for evaluating esophageal varices. It offers detailed cross-sectional images and is widely available, providing a broader assessment of abdominal pathology. Its non-invasive nature makes it particularly appealing for patients who contraindicated to endoscopy .

研究设计

研究类型
Observational
观察模型
Other
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Cirrhotic patients with portal hypertension undergoing upper GI endoscopy.

排除标准

  • Contraindication to contrast:( severe renal insufficiency, allergy to contrast agents).
  • Previous history of upper GI endoscopy with intervention (band ligation or sclerotherapy).-
  • Pregnancy.
  • Patients with previous transjagular intrahepatic portosystemic shunt (TIPS).
  • Patients with contraindication to endoscopy (severe cardiopulmonary conditions, coma "unless the patient is intubated", and cardiac arrhythmias)

结局指标

主要结局

Comparison between CT and endscopy in esophageal varices

时间窗: Baseline

Agreement between MDCT and endoscopy in the grading of esophageal varices

次要结局

  • Assessment other complication of varicesand cirrhosis in CT(Baseline)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Dina Saad Wally

Resident Doctor

Assiut University

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