Cardiovascular Research Consortium - a Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 1,001
- 试验地点
- 1
- 主要终点
- Atrial fibrillation
研究概览
简要总结
The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.
详细描述
The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any open-heart cardiac surgery
- •Written informed consent
- •All-comers design
排除标准
- •No informed consent
结局指标
主要结局
Atrial fibrillation
时间窗: postoperatively until 5 years follow-up
Occurrence of atrial fibrillation
次要结局
- All-cause Mortality(postoperatively until 5 years follow-up)
- Transient ischemic attack(postoperatively until 5 years follow-up)
- Stroke(postoperatively until 5 years follow-up)
- Myocardial infarction(postoperatively until 5 years follow-up)
- Target vessel revascularization(postoperatively until 5 years follow-up)
- Post-pericardiotomy syndrome(postoperatively until 1 years follow-up)
研究者
Tuomas Kiviniemi
Cardiologist, MD, PhD, FESC
University of Turku