Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) at different magnetic field strengths in healthy volunteers

Completed

• Conditions: lymph node cancer; Malignant lymphomas; 10025323; Het betreft onderzoek naar beeldkwaliteit en normale lymfeklieren bij gezonde vrijwilligers

• Registration Number: NL-OMON31117
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

- male or female volunteers
- age: 18 years and older
- the participant must willingly give written informed consent prior to the start of the study

Exclusion Criteria

- volunteers who underwent surgery in the past
- volunteers who had a malignancy in the past
- volunteers who have been or are suffering from a chronical inflammation or infection
- volunteers using medication at present
- volunteers who suffered from a transient infection within the past two months
- volunteers with symptoms possibly indicating an active inflammation or infection (e.g. fever, chills, night sweats, malaise, weight loss, fatigue, rhinorrhoe, coughing, throat ache, nausea, vomiting, diarrhea, etc.)
- volunteers with a general contraindication for MRI (including cardiovascular pacemakers, claustrofobia)
-volunteers who don't want to be informed about incidentally discovered lesions
-employees of the Department of Radiology of the UMC Utrecht

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1 a) Image quality of DWIBS obtained at different magnetic field strengths and<br /><br>with different fat-suppression techniques: average apparent contrast-to-noise<br /><br>ratio's with corresponding standard deviations of DWIBS-images obtained at<br /><br>1.0 T, 1.5 T, and 3.0 T and with different fat-suppression techniques (STIR<br /><br>versus SPIR/SPAIR) will be compared<br /><br><br /><br>1 b) Image quality of three respiration techniques in DWIBS of the liver: image<br /><br>quality on a scale of 1 (poor) to 5 (very good) of breathhold, respiratory<br /><br>triggered, and free breathing scanning will be compared<br /><br><br /><br>2) A mean ADC with SD will be calculated for non-malignant (normal) lymph<br /><br>nodes.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The number of non-analyzable images will be registered.</p><br>