ACTRN12621001213831
Recruiting
未知
Does treatment for moderate to severe obstructive sleep apnoea (OSA) improve heart rhythm control in patients following a catheter ablation for Atrial Fibrillation (AF) (SNORE-AF study)
Melbourne Health (Royal Melbourne Hospital)0 sites220 target enrollmentSeptember 10, 2021
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Atrial Fibrillation
- Sponsor
- Melbourne Health (Royal Melbourne Hospital)
- Enrollment
- 220
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Paroxysmal or persistent atrial fibrillation referred for AF ablation. By definition this will include highly symptomatic patients with paroxysmal or persistent AF (ablation is completed as standard of care treatment and not a research study related procedure).
- •2\.Moderate to severe predominant OSA defined as AHI 15 or greater and a central apnoea index/total apnoea index less than 20 percent (diagnosed by either in lab Polysomnography (PSG) or at home WatchPAT device)
- •3\.Age 18 years to less than 80 years old
- •4\.Able and willing to provide informed consent and comply with all testing and requirements.
- •5\.Willing to use CPAP if randomised to the treatment arm
- •6\.Willing to defer CPAP treatment by up to 12 months if randomised to the non\-treatment arm.
Exclusion Criteria
- •1\.History of prior AF ablation procedure
- •2\.Presence of other significant structural heart disease
- •a.Valvular heart disease ( moderate valvular regurgitation or stenosis)
- •b.Heart failure (Ejection fraction less than 45%; NYHA class 3 or 4\)
- •c.Surgically corrected congenital heart disease (eg ASD repair)
- •d.Hypertrophic cardiomyopathy
- •e.Unstable coronary artery disease
- •f.Severe left atrial enlargement (LA diameter greater than 5\.5cm)
- •3\.Presence of other major comorbidities
- •a.Renal failure (eGFR less than 50\)
Outcomes
Primary Outcomes
Not specified
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