ACTRN12612000548831已完成未知
In patients with exacerbation of chronic obstructive pulmonary disease (COPD) who have abnormal cardiac biomarkers, compared to those who do not have abnormal cardiac biomarkers and those who do not receive ventilatory support, do the abnormalities of cardiac biomarkers normalise when the patients are in stable COPD, do they reflect underlying abnormal cardiac function and do they have higher morbidity and mortality rate?
Department of Respiratory Medicine, Waikato Hospital0 个研究点目标入组 120 人开始时间: 2012年5月23日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 40 Years 至 o limit（—）
- 性别
- All
入选标准
- •Physician diagnosis of COPD.
- •Fixed airflow obstruction (FEV1/FVC <70% and FEV1<80% of predicted) at presentation, in the last 6 months or at 30-day follow up.
- •Over 40 years of age.
- •At least 10pack years smoking history.
- •Acute exacerbation of COPD as defined by dyspnoea, cough or sputum purulence severe enough to warrant hospital admission, respiratory failure or change in mental status due to COPD.
- •In the patients receiving non-invasive ventilation, arterial blood gas indices of hypercapnic respiratory failure.
排除标准
- •Respiratory physician diagnosis of interstitial lung disease or bronchiectasis.
- •Radiological diagnosis of pneumonia.
- •Known diagnosis of clinically significant valvular heart disease.
- •Known diagnosis of other terminal illness with prognosis less than 2 years.
- •Inability to perform spirometry.
- •Patient refusal to participate in the study or unable to give informed consent.
- •Likely to leave Waikato region or become uncontactable during follow-up period.
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