Effect of Treatments in Patients Hospitalized for Severe COVID-19 Pneumonia: a Multicenter Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 400
- 试验地点
- 2
- 主要终点
- Composite of death and mechanical ventilation
研究概览
简要总结
Several treatments have been used in during the Covid-19 pandemic of 2020. Using patients' registries from several hospitals in Paris, the investigators retrospectively analyzed associations between specific treatments, including but not limited to vaccines targeted against SARS-CoV-2, hydroxychloroquine, azithromycin, remdesivir, baricitinib, tocilizumab, sarilumab, lopinavir/ritonavir and oseltamivir; and clinical outcomes including, death and mechanical ventilation.
详细描述
Several treatments have been used in during the Covid-19 pandemic of 2020. Using patients' registries from several hospitals in Paris, the investigators retrospectively analyzed associations between specific treatments, including but not limited to vaccines targeted against SARS-CoV-2, hydroxychloroquine, azithromycin, remdesivir, baricitinib, tocilizumab, sarilumab, lopinavir/ritonavir and oseltamivir; and clinical outcomes including, death and mechanical ventilation.
Other outcomes of interest include: acute kidney injury, encephalopathy, need for intensive care unit transfers.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •admitted for severe Covid-19 pneumonia (i.e. requiring O2-support more than 6L/min with SpO2<96%)
排除标准
- •patients who were previously in ICU
- •patients already hospitalized prior to study start date
- •patients in palliative care
- •lack of consent
结局指标
主要结局
Composite of death and mechanical ventilation
时间窗: 14-days follow-up
Composite of death and mechanical ventilation (i.e. intubation)
次要结局
- Mechanical ventilation(14-days follow-up)
- Composite of death and mechanical ventilation(28-days follow-up)
- World Health Organization score(28-days follow-up)
- Death(14-days follow-up)
研究者
Lee S Nguyen
Study coordinator
Groupe Hospitalier Pitie-Salpetriere