Effect of Treatments in Patients Hospitalized for Severe COVID-19 Pneumonia: a Multicenter Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Covid-19
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
- Enrollment
- 400
- Locations
- 2
- Primary Endpoint
- Composite of death and mechanical ventilation
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Several treatments have been used in during the Covid-19 pandemic of 2020. Using patients' registries from several hospitals in Paris, the investigators retrospectively analyzed associations between specific treatments, including but not limited to vaccines targeted against SARS-CoV-2, hydroxychloroquine, azithromycin, remdesivir, baricitinib, tocilizumab, sarilumab, lopinavir/ritonavir and oseltamivir; and clinical outcomes including, death and mechanical ventilation.
Detailed Description
Several treatments have been used in during the Covid-19 pandemic of 2020. Using patients' registries from several hospitals in Paris, the investigators retrospectively analyzed associations between specific treatments, including but not limited to vaccines targeted against SARS-CoV-2, hydroxychloroquine, azithromycin, remdesivir, baricitinib, tocilizumab, sarilumab, lopinavir/ritonavir and oseltamivir; and clinical outcomes including, death and mechanical ventilation. Other outcomes of interest include: acute kidney injury, encephalopathy, need for intensive care unit transfers.
Investigators
Lee S Nguyen
Study coordinator
Groupe Hospitalier Pitie-Salpetriere
Eligibility Criteria
Inclusion Criteria
- •admitted for severe Covid-19 pneumonia (i.e. requiring O2-support more than 6L/min with SpO2\<96%)
Exclusion Criteria
- •patients who were previously in ICU
- •patients already hospitalized prior to study start date
- •patients in palliative care
- •lack of consent
Outcomes
Primary Outcomes
Composite of death and mechanical ventilation
Time Frame: 14-days follow-up
Composite of death and mechanical ventilation (i.e. intubation)
Secondary Outcomes
- Mechanical ventilation(14-days follow-up)
- Composite of death and mechanical ventilation(28-days follow-up)
- World Health Organization score(28-days follow-up)
- Death(14-days follow-up)