Factors Associated With Clinical Outcomes in Patients Hospitalized for Covid-19 in GHT-93 Est
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 143
- 试验地点
- 2
- 主要终点
- Composite of death and mechanical ventilation
研究概览
简要总结
Healthcare centers treated several hundreds of patients with Covid-19 and prospectively gathered information in electronic format between March, 2020 to April, 2020. In the course of Covid-19 treatment, physicians employed several drugs, including hydroxychloroquine, azithromycin, lopinavir/ritonavir, tocilizumab, baricitinib, sarilumab, corticosteroids and systematic antibiotics (list is not exhaustive).
This cohort study aims to assess factors associated with clinical outcomes in patients hospitalized for Covid-19, by analyzing associations between treatments and outcomes.
All data are collected in electronical records during routine practice.
详细描述
Healthcare centers treated several hundreds of patients with Covid-19 and prospectively gathered information in electronic format between March, 2020 to April, 2020. In the course of Covid-19 treatment, physicians employed several drugs, including hydroxychloroquine, azithromycin, lopinavir/ritonavir, tocilizumab, baricitinib, sarilumab, corticosteroids and systematic antibiotics (list is not exhaustive).
This cohort study aims to assess factors associated with clinical outcomes in patients hospitalized for Covid-19.
Risk factors which will be studied include: baseline characteristics such as medical history and drugs with corresponding administration protocols.
Main outcomes include all-cause mortality, need for mechanical ventilation, for ICU transfer and all relevant biological syndromes.
All data are collected in electronical records during routine practice and additional data may be collected retrospectively.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hospitalized for Covid-19
- •severe pneumonia defined as pulse O2 < 96% despite > 6L/min
排除标准
- •lack of consent
- •palliative care patients
- •patients in ICU
- •patients transferred from ICU
结局指标
主要结局
Composite of death and mechanical ventilation
时间窗: At 14-days follow-up
Composite of death and mechanical ventilation
次要结局
- Death(At 14-days follow-up)
- Need for mechanical ventilation(At 14-days follow-up)
- Acute kidney injury(At 14-days follow-up)
- Acute respiratory distress syndrome(At 14-days follow-up)
- Cardiac arrhythmia and conduction disorder(At 14-days follow-up)
- Composite of death and mechanical ventilation(Up to 60 days after inclusion)
- 60-days mortality(Up to 60 days after inclusion)
- 60-days mechanical ventilation(Up to 60 days after inclusion)
研究者
Dr. Hélène GROS
Principal Investigator
Centre Hospitalier Intercommunal Robert Ballanger