Factors Associated With Clinical Outcomes in Patients Hospitalized for Covid-19 in GHT-93 Est
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COVID
- Sponsor
- Centre Hospitalier Intercommunal Robert Ballanger
- Enrollment
- 143
- Locations
- 2
- Primary Endpoint
- Composite of death and mechanical ventilation
- Last Updated
- 6 years ago
Overview
Brief Summary
Healthcare centers treated several hundreds of patients with Covid-19 and prospectively gathered information in electronic format between March, 2020 to April, 2020. In the course of Covid-19 treatment, physicians employed several drugs, including hydroxychloroquine, azithromycin, lopinavir/ritonavir, tocilizumab, baricitinib, sarilumab, corticosteroids and systematic antibiotics (list is not exhaustive).
This cohort study aims to assess factors associated with clinical outcomes in patients hospitalized for Covid-19, by analyzing associations between treatments and outcomes.
All data are collected in electronical records during routine practice.
Detailed Description
Healthcare centers treated several hundreds of patients with Covid-19 and prospectively gathered information in electronic format between March, 2020 to April, 2020. In the course of Covid-19 treatment, physicians employed several drugs, including hydroxychloroquine, azithromycin, lopinavir/ritonavir, tocilizumab, baricitinib, sarilumab, corticosteroids and systematic antibiotics (list is not exhaustive). This cohort study aims to assess factors associated with clinical outcomes in patients hospitalized for Covid-19. Risk factors which will be studied include: baseline characteristics such as medical history and drugs with corresponding administration protocols. Main outcomes include all-cause mortality, need for mechanical ventilation, for ICU transfer and all relevant biological syndromes. All data are collected in electronical records during routine practice and additional data may be collected retrospectively.
Investigators
Dr. Hélène GROS
Principal Investigator
Centre Hospitalier Intercommunal Robert Ballanger
Eligibility Criteria
Inclusion Criteria
- •hospitalized for Covid-19
- •severe pneumonia defined as pulse O2 \< 96% despite \> 6L/min
Exclusion Criteria
- •lack of consent
- •palliative care patients
- •patients in ICU
- •patients transferred from ICU
Outcomes
Primary Outcomes
Composite of death and mechanical ventilation
Time Frame: At 14-days follow-up
Composite of death and mechanical ventilation
Secondary Outcomes
- Death(At 14-days follow-up)
- Need for mechanical ventilation(At 14-days follow-up)
- Acute kidney injury(At 14-days follow-up)
- Acute respiratory distress syndrome(At 14-days follow-up)
- Cardiac arrhythmia and conduction disorder(At 14-days follow-up)
- Composite of death and mechanical ventilation(Up to 60 days after inclusion)
- 60-days mortality(Up to 60 days after inclusion)
- 60-days mechanical ventilation(Up to 60 days after inclusion)