The Effects of Butyrate Enemas on Visceral Perception
- Registration Number
- NCT00726817
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
During this double blind, placebo controlled, randomised cross over study, healthy volunteers received an enema once daily for one week containing either placebo (saline), 50mM butyrate or 100mM of butyrate. Before and directly after each test period a barostat protocol was performed to measure parameters for visceral perception.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11
Inclusion Criteria
- healthy
Exclusion Criteria
- age, under 18 or over 65
- use of pre- or probiotics during study and 3 months previous to study
- previous bowel complaints
- gastrointestinal disease or abdominal surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 2 Butyrate enemas, once daily, containing 50mM butyrate 1 Butyrate enemas, once daily, containing saline 3 Butyrate enemas, once daily, containing 100mM butyrate
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Maastricht University
🇳🇱Maastricht, Limburg, Netherlands