Effect of a Butyrate Enema on the Systemic Concentration of Short Chain Fatty Acids
Not Applicable
Completed
- Conditions
- SCFA Metabolism
- Registration Number
- NCT02271802
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
In this placebo-controlled randomized parallel study the effects of a butyrate enema on plasma short-chain fatty acids (SCFA) concentrations and fluxes from portal drained viscera, liver and the splanchnic area are investigated
- Detailed Description
Patients undergoing upper abdominal surgery are included. During surgery they receive a butyrate enema or placebo enema. Before and after rectal administration, plasma samples are taken from several veins and arteries to analyse SCFA concentrations and fluxes from portal drained viscera, liver and the splanchnic area.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- patients undergoing open liver resection or pancreaticoduodenectomy
Exclusion Criteria
- known parenchymal liver disease
- presence of ileostomy or colostomy
- patients with inflammatory bowel disease
- antibiotics, prebiotics or probiotics 2 months prior to surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Plasma SCFAs 0, 5, 15, 30 min after administration
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Maastricht University
🇳🇱Maastricht, Netherlands
Maastricht University🇳🇱Maastricht, Netherlands