Decipher Epithelial Transformation by genotoxic Escherichia coli in precursors of Colonic Tumors
Recruiting
- Conditions
- D12.6Colon, unspecified
- Registration Number
- DRKS00030958
- Lead Sponsor
- niversitätsklinikum Heidelberg, Klinik Kinderheilkunde I
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Patients (<20years) with a genetically confirmed diagnosis of familial adenomatous polyposis coli in the premalignant stage who receive an endoscopic examination of the lower (or upper) gastrointestinal tract as part of routine care.
In case of inclusion of a pediatric patient, inclusion of the patient mother of a pediatric patient included in the study.
Written informed consent of the legal representative, as well as (if age-related reasonably possible) of the patient.
Exclusion Criteria
Refusal of consent
Presence of an infectious disease
Impossibility of obtaining biomaterial during endoscopy (e.g., discontinuation of the examination for non-study-related reasons)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Detection of DNA of colibactin-forming bacteria in polyp material, association with the presence of early somatic mutations using organoid lines from patient material.<br>
- Secondary Outcome Measures
Name Time Method Detection of additional genotoxic bacteria and association with the presence of early somatic mutations. Generation of organoids from patient materials. Correlation of DNA genotoxic in stool of patient mothers with presence in children.<br>