EMT markers expression in oral cancers
Not Applicable
- Conditions
- Health Condition 1: C040- Malignant neoplasm of anterior floor of mouthHealth Condition 2: C060- Malignant neoplasm of cheek mucosaHealth Condition 3: C039- Malignant neoplasm of gum, unspecifiedHealth Condition 4: C009- Malignant neoplasm of lip, unspecifiedHealth Condition 5: C031- Malignant neoplasm of lower gumHealth Condition 6: C030- Malignant neoplasm of upper gum
- Registration Number
- CTRI/2020/11/029361
- Lead Sponsor
- AIIMS Rishikesh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Age â?? 18 to 70 years
2.Biopsy proven OSCC planned for upfront surgery
3.ECOG-PS 0-2
Exclusion Criteria
1.History any prior cancer directed treatment
2.Any history of prior head or neck surgery.
3.Patient not willing to participate in the study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.To identify the expression of Epithelial Mesenchymal Transition (EMT) markers in oral squamous cell carcinoma (OSCC).Timepoint: 18 months - patient accrual <br/ ><br>36 months - data collection and analysis
- Secondary Outcome Measures
Name Time Method 1.To study EMT markers expression status in relation to OSCC stage. <br/ ><br> <br/ ><br>Timepoint: 18 months - patient accrual <br/ ><br>36 months - data collection and analysis;To determine EMT markers expression role in predicting loco regional failure and survivalTimepoint: 18 months - patient accrual <br/ ><br>36 months - data collection and analysis;To study correlation of EMT markers expression wit histopathological factors. <br/ ><br>Timepoint: 18 months - patient accrual <br/ ><br>36 months - data collection and analysis;To study correlation of EMT markers expression with Tobacco abuse and HPV status <br/ ><br>Timepoint: 18 months - Patient Accrual <br/ ><br>36 months - Data collection and analysis