Hyperemesis In Pregnancy (HIP) Trial: Inpatient versus outpatient management of severe nausea and vomiting in pregnancy
Not Applicable
Completed
- Conditions
- Hyperemesis gravidarum (severe nausea and vomiting of pregnancy)Pregnancy and Childbirth
- Registration Number
- ISRCTN24659467
- Lead Sponsor
- Chelsea and Westminster NHS Trust (UK)
- Brief Summary
2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/29222135
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 120
Inclusion Criteria
Pregnant women up to 20 weeks gestation with symptoms of hyperemesis gravidarum and at least 1+ ketonuria on dipstick
Exclusion Criteria
1. Women greater than 20 weeks gestation
2. Women with another medical condition manifesting as nausea and vomiting such as UTI
3. Type 1 or 2 diabetes
4. Potassium < 3.2 mmol/l
5. Sodium < 130 mmol/l
6. Abnormal liver function tests (associated with increased severity of HG)
7. Abnormal thyroid function tests (associated with increased severity of HG)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction in Pregnancy Unique Emesis Score (PUQE score) at 48 hours
- Secondary Outcome Measures
Name Time Method 1. Number of days intravenous fluid treatment needed<br>2. Number with ketonuria at 48 hours<br>3. Improvement, at 2 and 7 days from start of treatment, in:<br>3.1. Pregnancy-unique quantification of emesis and nausea (PUQE) score<br>3.2. Drinking and eating scores<br>3.3. Wellbeing rating<br>4. Weight change at 7 days<br>5. Number still taking antiemetics at one week following discharge<br>6. Re-attendance episodes for hyperemesis in the seven days following discharge<br>7. Costs of treatment