NCT05323227Unknown不适用
Association of Lipoprotein (a) With Coronary CTA Assessed High Risk Coronary Disease Attributes and Cardiovascular Outcomes
Shanghai Zhongshan Hospital1 个研究点 分布在 1 个国家目标入组 378 人开始时间: 2016年3月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 378
- 试验地点
- 1
- 主要终点
- Association of Lp(a) level with CCTA measured Parameters
研究概览
简要总结
Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular events, although the underlying mechanism remains unclear. This study evaluated the relationship between Lp(a) and high-risk attributes (HRA) by coronary computed tomography angiography (CCTA) as well as their prognostic value.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with Lp(a) meaured within 1 week of CCTA examination.
排除标准
- •unstable angina pectoris
- •acute myocardial infarction
- •New York Heart Association class III-IV heart failure
- •with a history of bypass surgery
- •active infection
- •respiratory failure
- •chronic kidney disease (estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2)
- •liver dysfunction (liver enzyme >3 upper reference limit [URL] or bilirubin >2 URL)
- •malignancy
- •systemic connective tissue disease
- •poor CCTA imaging quality not suitable for analysis
- •other situations not suitable for the study
结局指标
主要结局
Association of Lp(a) level with CCTA measured Parameters
时间窗: at the index procedure
Association of Lp(a) level with CCTA measured high-risk plaque characteristics
Major adverse cardiac events
时间窗: at 24 months from index procedure
a composite of cardiac death, any myocardial infarction, and stroke
次要结局
- Cardiac death(at 24 months from index procedure)
- Myocardial infarction(at 24 months from index procedure)
- Stroke(at 24 months from index procedure)
研究者
研究点 (1)
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