A randomised trial comparing two strategies for preventing kidney failure after angioplasty

Completed

• Conditions: Kidney function impairment/coronary artery disease/contrast-induced nephropathy; Urological and Genital Diseases; Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions

• Registration Number: ISRCTN15027862
• Lead Sponsor: iverpool Heart and Chest Hospital NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-07-15
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Male and female patients aged 18 years or over
2. Estimated glomerular filtration rate (eGFR) less than 60 ml/m (as calculated by modified Modification of Diet in Renal Disease [MDRD] equation with local laboratory correction factor)

Exclusion Criteria

1. Patients who had coronary angiography or other procedure with contrast exposure (computed tomography pulmonary angiography [CTPA] etc.) within 2 weeks of percutaneous coronary intervention (PCI)
2. Unable to consent
3. Patient undergoing cardiac surgery
4. Cardiogenic shock
5. Unlikely to attend for follow-up blood tests
6. Presence of non-cardiac illness that might affect life expectancy
7. Any previous allergic reaction to contrast media or N-acetylcysteine (NAC)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eGFR at 6 months

Secondary Outcome Measures

Name	Time	Method
1. Contrast-induced nephropathy. Total duration of follow-up: 6 months.<br>2. eGFR at 14 days<br>3. Major Adverse Cardiovascular Events (MACE) ? death, myocardial infarction (MI), stroke, and repeat revascularisation. Total duration of follow-up: 6 months.<br>4. Renal replacement therapy. Total duration of follow-up: 6 months.