Skip to main content
MedPathMedPath Home
Clinical Trials/ISRCTN15027862
ISRCTN15027862
Completed
Not Applicable

A randomised factorial trial of N-acetylcysteine prophylaxis and iso-osmolar versus low-osmolar contrast media on kidney function in patients at risk of contrast-induced nephropathy following cardiac catheterisation for percutaneous coronary interventions

iverpool Heart and Chest Hospital NHS Trust (UK)0 sites200 target enrollmentJuly 15, 2009
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
ConditionsKidney function impairment/coronary artery disease/contrast-induced nephropathyUrological and Genital DiseasesDrug- and heavy-metal-induced tubulo-interstitial and tubular conditions

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Kidney function impairment/coronary artery disease/contrast-induced nephropathy
Sponsor
iverpool Heart and Chest Hospital NHS Trust (UK)
Enrollment
200
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
July 15, 2009
End Date
TBD
Last Updated
11 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
iverpool Heart and Chest Hospital NHS Trust (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. Male and female patients aged 18 years or over
  • •2\. Estimated glomerular filtration rate (eGFR) less than 60 ml/m (as calculated by modified Modification of Diet in Renal Disease \[MDRD] equation with local laboratory correction factor)

Exclusion Criteria

  • •1\. Patients who had coronary angiography or other procedure with contrast exposure (computed tomography pulmonary angiography \[CTPA] etc.) within 2 weeks of percutaneous coronary intervention (PCI)
  • •2\. Unable to consent
  • •3\. Patient undergoing cardiac surgery
  • •4\. Cardiogenic shock
  • •5\. Unlikely to attend for follow\-up blood tests
  • •6\. Presence of non\-cardiac illness that might affect life expectancy
  • •7\. Any previous allergic reaction to contrast media or N\-acetylcysteine (NAC)

Outcomes

Primary Outcomes

Not specified

Similar Trials

Active, not recruiting
Not Applicable
A randomised factorial trial of N-acetylcysteine prophylaxis and iso-osmolar versus low-osmolar contrast media on kidney function in patients at risk of contrast induced nephropathy following cardiac catheterisation for percutaneous coronary interventions - the CON NEC T” trial - CONNECT
EUCTR2009-011175-70-GBiverpool Heart and Chest Hospital
Completed
Not Applicable
A randomised controlled study of N-Acetylcysteine in liver transplantatioSurgery: Liver transplantSurgeryLiver transplant
ISRCTN46492332Record provided by the NHS Trusts Clinical Trials Register - Department of Health (UK)170
Completed
Not Applicable
Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease.Chronic obstructive pulmonary diseaseRespiratoryPulmonary disease
ISRCTN21676344Health Research Council of New Zealand50
Recruiting
Phase 2
The Post Anaesthesia N-Acetycysteine Cognitive Evaluation trial, investigating the potential for N-Acetylcysteine to reduce cognitive dysfunction following major elective non-cardiac surgeryPost Operative Cognitive DysfunctionSurgical Stress ResponsePost Operative Mood DisorderPost surgical painAnaesthesiology - AnaestheticsMental Health - Studies of normal psychology, cognitive function and behaviourSurgery - Other surgery
ACTRN12614000411640The Geelong Hospital370
Recruiting
Phase 2
Treatment using N-acetyl cysteine (Injection) to reduce occurrence of muscle weakness and death in patients admitted with organophosphate (OP) pesticide poisoning.Health Condition 1: T600- Toxic effect of organophosphate and carbamate insecticides
CTRI/2020/09/028060Christian medical college Vellore