Genetics of Rheumatoid Arthritis Registry
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,062
- 试验地点
- 1
- 主要终点
- Genetic Association with risk for rheumatoid arthritis
研究概览
简要总结
Many genes are thought to contribute to rheumatoid arthritis (RA). This study will attempt to identify genes that may contribute to RA.
详细描述
The identification of genes for complex disorders such as RA requires large numbers of genetically informative families. This study enrolls people diagnosed with with RA and their families.
This study will enroll 1000 RA patients and their parents. Participants with RA will be evaluated at his or her doctor's office or other location convenient for the participant. Participants will have a brief phone interview with a study coordinator and a blood sample will be obtained. Disease evaluation will be done at one visit and will include confirmation of diagnosis, a 28 joint count, joint alignment and mobility score (JAMS) and administration of a health assessment questionnaire.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult onset RA
- •Diagnosis of RA made between 18 and 60 years old
- •Both parents alive and willing to participate
- •Parents may have diagnosis of RA (affected) or be unaffected
排除标准
- •Inflammatory bowel disease
- •Psoriatic arthritis
结局指标
主要结局
Genetic Association with risk for rheumatoid arthritis
时间窗: 10 years
The project aims to identify risk alleles for rheumatoid arthritis using association methods in trio families, combined with data from singleton cases and multiplex families
次要结局
未报告次要终点
研究者
Peter Gregersen
Center Head, Robert S Boas Center for Genomics and Human Genetics
Northwell Health