Genetics and Mechanisms of Rheumatoid Arthritis

Completed

• Conditions: Leukocytes, Mononuclear; Genetic Association Studies; Rheumatoid Arthritis

• Registration Number: NCT01788098
• Lead Sponsor: Slovak Academy of Sciences

Brief Summary

The study is aimed at revealing genetic background in rheumatoid arthritis (RA). For that purpose samples of DNA will be collected from 500 RA patients and similar number of controls from whole Slovakia. Variations in several genes associated with RA will be evaluated. The second aim is to assess functional changes in immune cells from selected patients and their evaluation together with genetic background. The project has observational character without any intention to change the treatment of RA patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-10
• Primary Completion: 2012-06
• Study Completion: 2012-12
• Status Verified: 2013-02
• Study First Submitted: 2013-02-03
• Study First Submitted QC: 2013-02-07
• Last Update Submitted: 2013-02-07
• Study First Posted: 2013-02-11
• Last Update Posted: 2013-02-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 790

Inclusion Criteria

• rheumatoid arthritis or healthy

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Genetic association	1 day	Association of selected single nucleotide polymorphisms with rheumatoid arthritis.

Secondary Outcome Measures

Name	Time	Method
Peripheral blood mononuclear cells reactivity	1 day	Reactivity and functional changes of peripheral blood mononuclear cells obtained from patients with rheumatoid arthritis in comparison to healthy controls.

Trial Locations

Locations (1)

Slovak Academy of Sciences, Center for Molecular Medicine; 🇸🇰 Bratislava, Slovakia