Neutrophil Extracellular Traps and Sickle Cell Disease

• Conditions: Sickle Cell Anemia

• Registration Number: NCT02004808
• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary

NETs formation in vaso-occlusive events in sickle cell disease and the role of hydroxyurea treatment.The study hypothesis is that NETs formation by neutrophils has a role in the induction of vaso occlusive disease in blood vessels. It is possible that high leukocyte count in children with sickle cell anemia is a bad prognostic sign due to NETs formation supporting occlusion of peripheral and central blood vessels.Hydroxyurea treatment might prevent vaso occlusive syndrome not only by increasing HbF but also by decreasing neutrophil count and inhibiting NETs formation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-07
• Study First Submitted: 2013-10-15
• Study First Submitted QC: 2013-12-03
• Last Update Submitted: 2013-12-03
• Study First Posted: 2013-12-09
• Last Update Posted: 2013-12-09
• Study Start: 2014-02
• Primary Completion: 2019-12
• Study Completion: 2019-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• children who suffer from sickle cell disease and/or children with sickle cell disease treated with hydroxyurea

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
measurements of neutrophil function	at first admition (day 1)

Secondary Outcome Measures

Name	Time	Method
measurements of neutrophil function	at sickle cell crisis while hospitalized