Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment

Completed

• Conditions: Acromegaly; Excessive Growth Hormone Secretion; Insulin Resistance
• Interventions: Procedure: Transsphenoidal adenomectomy

• Registration Number: NCT00647179
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-02
• Study First Submitted: 2008-03-26
• Study First Submitted QC: 2008-03-28
• Study First Posted: 2008-03-31
• Primary Completion: 2016-12-07
• Study Completion: 2016-12-07
• Status Verified: 2017-12
• Last Update Submitted: 2017-12-22
• Last Update Posted: 2017-12-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• Written consent
• Age between 18 and 70
• Recently diagnosed with acromegaly

Exclusion Criteria

• NYHA 3
• Uncontrolled hypertension
• Known cerebrovascular disease
• Proliferative retinopatia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	Transsphenoidal adenomectomy	Patients recently diagnosed with acromegaly

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity	Before and after treatment

Secondary Outcome Measures

Name	Time	Method
QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism, Glucose tolerance	Before and after treatment

Trial Locations

Locations (1)

Department of Endocrinology, Aarhus University Hospital; 🇩🇰 Aarhus C, Aarhus, Denmark