Booster Study of COVID-19 Protein Subunit Recombinant Vaccine
- Conditions
- COVID-19
- Interventions
- Biological: Active ComparatorBiological: SARS-CoV-2 subunit protein recombinant vaccine
- Registration Number
- NCT05525208
- Lead Sponsor
- PT Bio Farma
- Brief Summary
Observer-blind, randomized, active-controlled prospective intervention study of Immunogenicity \& Safety of SARS-Cov-2 Protein Subunit Recombinant Vaccine (Bio Farma) as a Booster Dose Against COVID-19 in Adults 18 Years of Age and Older.
- Detailed Description
This trial is observer-blind, randomized, prospective intervention study. In this study 900 subjects who had received complete primary doses of authorized/approved inactivated (Sinovac®), mRNA (Pfizer®), or viral vector (AstraZeneca®) COVID-19 vaccine and willing to participate in the booster study by signing the consent form, will be involved in this trial.
Subject will be divided into six groups, each 150 subjects per arm who had received a complete primary dose of inactivated (Sinovac®) vaccine, mRNA (Pfizer®) vaccine, or viral vector (AstraZeneca®) vaccine will receive one booster dose of SARS-CoV-2 subunit protein recombinant vaccine or active control.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 900
- Clinically healthy adults 18 years of age and older.
- Subjects who have previously received complete primary series of authorized/approved inactivated (Sinovac®), mRNA (Pfizer®), or viral vector COVID-19 vaccine (AstraZeneca®) with the last dose administered a minimum of 6 months prior to inclusion but not longer than 12 months prior to inclusion.
- Subjects have been informed properly regarding the study and signed the informed consent form.
- Subjects will commit to comply with the instructions of the investigator and the schedule of the trial.
- Subject concomitantly enrolled or scheduled to be enrolled in another trial.
- Subject who has received booster dose of COVID-19 vaccine.
- Subject who has history of COVID-19 in the last 3 months (based on anamnesis or other examinations).
- Evolving mild, moderate or severe illness, especially infectious disease or fever (body temperature ≥37.5℃, measured with infrared thermometer/thermal gun).
- Women who are pregnant or planning to become pregnant during the study period (judged by self-report of subjects and urine pregnancy test results).
- History of asthma, history of allergy to vaccines or vaccine ingredients, and severe adverse reactions to vaccines, such as urticaria, dyspnea, and angioneurotic edema.
- History of uncontrolled coagulopathy or blood disorders contraindicating intramuscular injection.
- Patients with serious chronic diseases (serious cardiovascular diseases, uncontrolled hypertension and diabetes, liver and kidney diseases, malignant tumors, etc) which according to the investigator might interfere with the assessment of the trial objectives.
- Subjects who have any history of confirmed or suspected immunosuppressive or immunodeficient state, or received in the previous 4 weeks a treatment likely to alter the immune response (intravenous immunoglobulins, blood-derived products or long-term corticosteroid therapy (> 2 weeks)).
- Subjects who have history of uncontrolled epilepsy or other progressive neurological disorders, such as Guillain-Barre Syndrome.
- Subjects receive any vaccination (other than COVID-19 vaccine) within 1 month before and after IP immunization.
- Subjects plan to move from the study area before the end of study period.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Primary dose of mRNA (Pfizer®) vaccine (2) Active Comparator Subject who had received a complete primary dose of mRNA (Pfizer®) vaccine Primary dose of Viral Vector (AstraZeneca®) vaccine (2) Active Comparator Subject who had received a complete primary dose of viral vector (AstraZeneca®) vaccine Primary dose of mRNA (Pfizer®) vaccine (1) SARS-CoV-2 subunit protein recombinant vaccine Subject who had received a complete primary dose of mRNA (Pfizer®) vaccine Primary dose of inactivated (Sinovac®) vaccine (2) Active Comparator Subject who had received a complete primary dose of inactivated (Sinovac®) vaccine Primary dose of inactivated (Sinovac®) vaccine (1) SARS-CoV-2 subunit protein recombinant vaccine Subject who had received a complete primary dose of inactivated (Sinovac®) vaccine Primary dose of Viral Vector (AstraZeneca®) vaccine (1) SARS-CoV-2 subunit protein recombinant vaccine Subject who had received a complete primary dose of viral vector (AstraZeneca®) vaccine
- Primary Outcome Measures
Name Time Method Immunogenicity of the candidate vaccine 14 days after booster vaccination Geometric Mean Titer (GMT) and GMT ratio of neutralizing antibody to the SARS-CoV-2
- Secondary Outcome Measures
Name Time Method Seropositive rate of the candidate vaccine Baseline, 14 days and 6 months after booster vaccination Seropositive rate of neutralizing antibody
Comparison of immunogenicity between candidate vaccine and control group Baseline, 14 days, and 6 months after booster vaccination Comparison of GMT, seroconversion rate, seropositive rate of neutralizing antibody and IgG antibody (RBD) between candidate vaccine and control group
Safety of the candidate vaccine 28 days after booster vaccination Percentage of subjects with solicited and unsolicited Adverse Events (AE)
Serious Adverse Event (SAE) of the vaccine 6 months after booster vaccination Percentage of subjects with at least 1 SAE
Seroconversion rate of the candidate vaccine baseline and 14 days after booster vaccination Seroconversion rate of IgG antibody (RBD)
Seropositive rate and GMT of candidate vaccine Baseline, 14 days, and 6 months after booster vaccination Seropositive rate and GMT of candidate vaccine
Trial Locations
- Locations (2)
Faculty of Medicine Universitas Padjadjaran
🇮🇩Bandung, West Java, Indonesia
Faculty of Medicine Universitas Udayana
🇮🇩Denpasar, Bali, Indonesia