Pilot Study Assessing Cognitive Function and Emotional Possessing in Patients With Bilateral Facial Palsy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- I-S-T-2000R- (intelligence-structure-test 2000R)
研究概览
简要总结
Based on recent findings that botulinum toxin injections in the cranial muscles might reduce emotional processing (Havas 2011), an increasing number of popular newspaper tabloids are suggesting a negative effect on cognition. The underlying research articles address the "facial feedback hypothesis". The hypothesis indicates that expressive behaviour, including facial mimic expressions influences the subject's brain via feedback. (Alam 2008) Other systemic neurological diseases, e.g of inflammatory origin, may lead to temporary bilateral facial nerve palsy (BF). During recovery process, the palsy usually remits completely.
The effect of bilateral facial muscle palsy on cognition and emotional possessing has never been evaluated.
The results of this pilot study might provide new information about the effect bilateral facial palsy on emotional processing and cognition and the facial feedback hypothesis.
The aim of this controlled pilot study is to assess cognitive function and emotional processing in patients with bilateral facial palsy. In addition, differences in cognitive function and emotional processing in patients with different manifestations of dystonia should be evaluated.
According to the facial feedback theory, paralysed mimic muscles might alter emotional processing. Therefore, investigators compare patients with bilateral facial muscle palsy and healthy controls. Investigators expect no influence of facial muscle palsy on cognitive functions in any of the tested groups; the investigators expect a mild impairment of emotional processing only in the patients group with bilateral facial muscle palsy (BEB and BF). In addition, the investigators expect no difference in emotional processing in patients with different manifestations of dystonia (BEB and CD) at remission. There might be a slight difference of emotional processing in patients with different manifestations of dystonia (BEB and CD) at time of prominent facial palsy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •willing to participate in this pilot trial
- •bilateral facial palsy
- •age 18-80 years
- •willing to participate in this pilot trial
- •gender and
- •education (duration of school attendance) matched
- •and/or cervical dystonia
排除标准
- •neurological or psychiatric comorbidity
- •psychotropic drugs
结局指标
主要结局
I-S-T-2000R- (intelligence-structure-test 2000R)
时间窗: up to four weeks
Test to evaluate Intelligence * Subtest "Matrixes" * Subtest "Analogies"
次要结局
- Beck's depression-inventory-II(up to four weeks)
- Apathy Evaluation Scale(up to four weeks)
研究者
Kirsten Elwischger, MD
Dr. Kirsten Elwischger
Medical University of Vienna